Document Detail


Slowly and rapidly digestible starchy foods can elicit a similar glycemic response because of differential tissue glucose uptake in healthy men.
MedLine Citation:
PMID:  22990033     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Previously we observed that the consumption of pasta and bread resulted in a similar glycemic response, despite a slower intestinal influx rate of glucose from the pasta. Underlying mechanisms of this effect were not clear.
OBJECTIVE: The objective was to investigate the differences in glucose kinetics and hormonal response after consumption of products with slow and rapid in vivo starch digestibility but with a similar glycemic response.
DESIGN: Ten healthy male volunteers participated in a crossover study and consumed (13)C-enriched wheat bread or pasta while receiving a primed-continuous D-[6,6-(2)H(2)]glucose infusion. The dual-isotope technique enabled calculation of the following glucose kinetics: rate of appearance of exogenous glucose (RaE), endogenous glucose production, and glucose clearance rate (GCR). In addition, postprandial plasma concentrations of glucose, insulin, glucagon, and glucose-dependent insulinotropic polypeptide (GIP) were analyzed.
RESULTS: GIP concentrations after pasta consumption were lower than after bread consumption and strongly correlated with the RaE (r = 0.82, P < 0.01). The insulin response was also lower after pasta consumption (P < 0.01). In accordance with the low insulin response, the GCR was lower after pasta consumption, which explained the high glycemic response despite a low RaE.
CONCLUSIONS: Slower intestinal uptake of glucose from a starchy food product can result in lower postprandial insulin and GIP concentrations, but not necessarily in a lower glycemic response, because of a slower GCR. Even without being able to reduce postprandial glycemia, products with slowly digestible starch can have beneficial long-term effects. These types of starchy products cannot be identified by using the glycemic index and therefore another classification system may be necessary. This trial was registered at controlled-trials.com as ISRCTN42106325.
Authors:
Coby Eelderink; Marianne Schepers; Tom Preston; Roel J Vonk; Lizette Oudhuis; Marion G Priebe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-09-18
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  96     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-22     Completed Date:  2013-03-18     Revised Date:  2013-04-29    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1017-24     Citation Subset:  AIM; IM    
Affiliation:
Center for Medical Biomics, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Data Bank Information
Bank Name/Acc. No.:
ISRCTN/ISRCTN42106325
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MeSH Terms
Descriptor/Qualifier:
Blood Glucose / metabolism
Cross-Over Studies
Dietary Carbohydrates / administration & dosage*,  metabolism
Gas Chromatography-Mass Spectrometry
Gastric Inhibitory Polypeptide / blood
Glucagon / blood
Glucose / metabolism,  pharmacokinetics*
Glycemic Index*
Humans
Insulin / blood
Male
Postprandial Period
Regression Analysis
Starch / administration & dosage*,  pharmacokinetics
Young Adult
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Dietary Carbohydrates; 0/Insulin; 50-99-7/Glucose; 59392-49-3/Gastric Inhibitory Polypeptide; 9005-25-8/Starch; 9007-92-5/Glucagon
Comments/Corrections
Comment In:
Am J Clin Nutr. 2013 Apr;97(4):903-4
Am J Clin Nutr. 2013 Apr;97(4):902-3   [PMID:  23515393 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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