Document Detail

Slowly and rapidly digestible starchy foods can elicit a similar glycemic response because of differential tissue glucose uptake in healthy men.
MedLine Citation:
PMID:  22990033     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Previously we observed that the consumption of pasta and bread resulted in a similar glycemic response, despite a slower intestinal influx rate of glucose from the pasta. Underlying mechanisms of this effect were not clear.
OBJECTIVE: The objective was to investigate the differences in glucose kinetics and hormonal response after consumption of products with slow and rapid in vivo starch digestibility but with a similar glycemic response.
DESIGN: Ten healthy male volunteers participated in a crossover study and consumed (13)C-enriched wheat bread or pasta while receiving a primed-continuous D-[6,6-(2)H(2)]glucose infusion. The dual-isotope technique enabled calculation of the following glucose kinetics: rate of appearance of exogenous glucose (RaE), endogenous glucose production, and glucose clearance rate (GCR). In addition, postprandial plasma concentrations of glucose, insulin, glucagon, and glucose-dependent insulinotropic polypeptide (GIP) were analyzed.
RESULTS: GIP concentrations after pasta consumption were lower than after bread consumption and strongly correlated with the RaE (r = 0.82, P < 0.01). The insulin response was also lower after pasta consumption (P < 0.01). In accordance with the low insulin response, the GCR was lower after pasta consumption, which explained the high glycemic response despite a low RaE.
CONCLUSIONS: Slower intestinal uptake of glucose from a starchy food product can result in lower postprandial insulin and GIP concentrations, but not necessarily in a lower glycemic response, because of a slower GCR. Even without being able to reduce postprandial glycemia, products with slowly digestible starch can have beneficial long-term effects. These types of starchy products cannot be identified by using the glycemic index and therefore another classification system may be necessary. This trial was registered at as ISRCTN42106325.
Coby Eelderink; Marianne Schepers; Tom Preston; Roel J Vonk; Lizette Oudhuis; Marion G Priebe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-09-18
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  96     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-22     Completed Date:  2013-03-18     Revised Date:  2013-04-29    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1017-24     Citation Subset:  AIM; IM    
Center for Medical Biomics, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
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MeSH Terms
Blood Glucose / metabolism
Cross-Over Studies
Dietary Carbohydrates / administration & dosage*,  metabolism
Gas Chromatography-Mass Spectrometry
Gastric Inhibitory Polypeptide / blood
Glucagon / blood
Glucose / metabolism,  pharmacokinetics*
Glycemic Index*
Insulin / blood
Postprandial Period
Regression Analysis
Starch / administration & dosage*,  pharmacokinetics
Young Adult
Reg. No./Substance:
0/Blood Glucose; 0/Dietary Carbohydrates; 0/Insulin; 50-99-7/Glucose; 59392-49-3/Gastric Inhibitory Polypeptide; 9005-25-8/Starch; 9007-92-5/Glucagon
Comment In:
Am J Clin Nutr. 2013 Apr;97(4):903-4
Am J Clin Nutr. 2013 Apr;97(4):902-3   [PMID:  23515393 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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