| Slowly and rapidly digestible starchy foods can elicit a similar glycemic response because of differential tissue glucose uptake in healthy men. | |
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MedLine Citation:
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PMID: 22990033 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Previously we observed that the consumption of pasta and bread resulted in a similar glycemic response, despite a slower intestinal influx rate of glucose from the pasta. Underlying mechanisms of this effect were not clear. OBJECTIVE: The objective was to investigate the differences in glucose kinetics and hormonal response after consumption of products with slow and rapid in vivo starch digestibility but with a similar glycemic response. DESIGN: Ten healthy male volunteers participated in a crossover study and consumed (13)C-enriched wheat bread or pasta while receiving a primed-continuous D-[6,6-(2)H(2)]glucose infusion. The dual-isotope technique enabled calculation of the following glucose kinetics: rate of appearance of exogenous glucose (RaE), endogenous glucose production, and glucose clearance rate (GCR). In addition, postprandial plasma concentrations of glucose, insulin, glucagon, and glucose-dependent insulinotropic polypeptide (GIP) were analyzed. RESULTS: GIP concentrations after pasta consumption were lower than after bread consumption and strongly correlated with the RaE (r = 0.82, P < 0.01). The insulin response was also lower after pasta consumption (P < 0.01). In accordance with the low insulin response, the GCR was lower after pasta consumption, which explained the high glycemic response despite a low RaE. CONCLUSIONS: Slower intestinal uptake of glucose from a starchy food product can result in lower postprandial insulin and GIP concentrations, but not necessarily in a lower glycemic response, because of a slower GCR. Even without being able to reduce postprandial glycemia, products with slowly digestible starch can have beneficial long-term effects. These types of starchy products cannot be identified by using the glycemic index and therefore another classification system may be necessary. This trial was registered at controlled-trials.com as ISRCTN42106325. |
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Authors:
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Coby Eelderink; Marianne Schepers; Tom Preston; Roel J Vonk; Lizette Oudhuis; Marion G Priebe |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2012-09-18 |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 96 ISSN: 1938-3207 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-10-22 Completed Date: 2013-03-18 Revised Date: 2013-04-29 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 1017-24 Citation Subset: AIM; IM |
Affiliation:
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Center for Medical Biomics, University Medical Center Groningen, University of Groningen, Groningen, Netherlands. |
| Data Bank Information | |
Bank Name/Acc. No.:
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ISRCTN/ISRCTN42106325 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Glucose
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metabolism Cross-Over Studies Dietary Carbohydrates / administration & dosage*, metabolism Gas Chromatography-Mass Spectrometry Gastric Inhibitory Polypeptide / blood Glucagon / blood Glucose / metabolism, pharmacokinetics* Glycemic Index* Humans Insulin / blood Male Postprandial Period Regression Analysis Starch / administration & dosage*, pharmacokinetics Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Dietary Carbohydrates; 0/Insulin; 50-99-7/Glucose; 59392-49-3/Gastric Inhibitory Polypeptide; 9005-25-8/Starch; 9007-92-5/Glucagon |
| Comments/Corrections | |
Comment In:
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Am J Clin Nutr. 2013 Apr;97(4):903-4 Am J Clin Nutr. 2013 Apr;97(4):902-3 [PMID: 23515393 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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