Document Detail


Slowing progression of chronic kidney disease.
MedLine Citation:
PMID:  25019022     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Early identification of chronic kidney disease (CKD) provides an opportunity to implement therapies to improve kidney function and slow progression. The goal of this article is to review established and developing clinical therapies directed at slowing progression. The importance of controlling blood pressure will be discussed along with the target blood pressure that should be achieved in CKD patients. Therapy directed at inhibiting the renin-angiotensin-aldosterone system remains the mainstay of treatment with single-agent inhibition of this system being as good as dual blockade with fewer adverse effects. Other therapies that may be used include correction of metabolic acidosis, dietary protein restriction, and new models for delivering care to patients with CKD. Emerging therapies targeting endothelin, uric acid, kidney fibrosis, and oxidant stress hold promise for the future.
Authors:
Paul E Drawz; Mark E Rosenberg
Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Kidney international supplements     Volume:  3     ISSN:  2157-1724     ISO Abbreviation:  Kidney Int Suppl (2011)     Publication Date:  2013 Dec 
Date Detail:
Created Date:  2014-7-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101562008     Medline TA:  Kidney Int Suppl (2011)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  372-376     Citation Subset:  -    
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