Document Detail


Slowing of the heart during anaphylactic shock. A report of five cases.
MedLine Citation:
PMID:  3414348     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Five patients are reported with anaphylactic shock reactions due to i.v. administration of atracurium, methicillin, amidotrezoate (n = 2) and plasma. In these patients a fall in heart rate (HR) from 5-50 beats.min-1 was recorded during the hypotensive period. In three of the patients HR was 40 beats.min-1 or less, and in two of the patients a hypotensive bradycardiac episode spontaneously reappeared after normal HR and BP were established. Central venous pressure (CVP) fell in one patient from 0.8 to 0.6 kPa as HR and BP decreased while arterial oxygen tension remained normal. All patients were in a stable condition after treatment with volume expansion and sympathomimetic drugs. These observations indicate that anaphylactic shock is associated with a strong and sometimes persistent vagal tone to the heart in parallel with the early reaction to hypotensive hypovolaemic shock.
Authors:
J Jacobsen; N H Secher
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Acta anaesthesiologica Scandinavica     Volume:  32     ISSN:  0001-5172     ISO Abbreviation:  Acta Anaesthesiol Scand     Publication Date:  1988 Jul 
Date Detail:
Created Date:  1988-10-03     Completed Date:  1988-10-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370270     Medline TA:  Acta Anaesthesiol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  401-3     Citation Subset:  IM    
Affiliation:
Department of Anaesthesia, University of Copenhagen, Denmark.
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MeSH Terms
Descriptor/Qualifier:
Aged
Anaphylaxis / etiology*
Atracurium / adverse effects
Blood Transfusion / adverse effects
Bradycardia / etiology*
Child, Preschool
Diatrizoate / adverse effects
Female
Humans
Male
Methicillin / adverse effects
Middle Aged
Plasma
Chemical
Reg. No./Substance:
117-96-4/Diatrizoate; 61-32-5/Methicillin; 64228-79-1/Atracurium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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