Document Detail


Slower eating rate is independent to gastric emptying in obese minipigs.
MedLine Citation:
PMID:  20691715     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of our study was to investigate whether the altered eating behavior observed in the context of a diet-induced metabolic syndrome is related to changes of the gastric emptying and autonomic balance. Eight adult male Göttingen minipigs were subjected during 5months to ad libitum Western diet (WD). Several factors were compared between the lean (before WD) and obese conditions: general activity and eating behavior, gastric emptying, adiposity, glycemia and insulinemia during IVGTT, and heart rate variability (HRV). In our model, obesity did not alter the gastric emptying (258±26 vs. 256±14 min, P>0.10) but induced insulin resistance: increased basal insulinemia (12.6±0.8 to 36.6±6.1 mU/l, P<0.02) and reduced insulin sensitivity (4.5E-4±0.7E-4 to 2.5E-4±0.2E-4 min(-1) per mU.l(-1) of insulin, P<0.05). The HRV and sympathovagal balance were not significantly modified (P>0.10). Fed ad libitum with WD, animals overate durably (P<0.001). During a 30-min meal test though, the ingestion speed, the food ingested (1076±48 vs. 520±52 g) and energy intake decreased in the obese condition (P<0.05), which can be explained by the fragmentation of the daily caloric intake. These data suggest that the slower eating rate and increased number of meals observed in obese minipigs without neuropathy is independent to gastric emptying. The explanation may be sought rather in central modifications induced by obesity that might modify the food perception and/or motivation.
Authors:
D Val-Laillet; S Guérin; C H Malbert
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-08-05
Journal Detail:
Title:  Physiology & behavior     Volume:  101     ISSN:  1873-507X     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-04     Completed Date:  2011-01-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  462-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Affiliation:
INRA, UMR1079 SENAH, Domaine de la Prise, 35590 Saint Gilles, France. david.val-laillet@rennes.inra.fr
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MeSH Terms
Descriptor/Qualifier:
Adiposity / physiology
Animals
Blood Glucose / physiology
Feeding Behavior / physiology*
Gastric Emptying / physiology*
Hyperphagia / metabolism*,  physiopathology
Insulin / blood
Male
Metabolic Syndrome X / metabolism*,  physiopathology
Motivation / physiology
Obesity / metabolism,  physiopathology*
Statistics, Nonparametric
Swine
Swine, Miniature
Taste Perception / physiology
Time Factors
Vagus Nerve / physiology
Chemical
Reg. No./Substance:
0/Blood Glucose; 11061-68-0/Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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