Document Detail

Slow versus rapid enteral feeding advancement in preterm newborn infants 1000-1499 g: a randomized controlled trial.
MedLine Citation:
PMID:  20002013     Owner:  NLM     Status:  MEDLINE    
AIM: To evaluate whether preterm neonates weighing 1000-1499 g at birth receiving rapid enteral feeding advancement at 30 mL/kg/day attain full feedings (180 mL/kg/day) earlier than those receiving slow enteral feeding advancement at 20 mL/kg/day without increase in the incidence of feeding intolerance or necrotizing enterocolitis.
METHODS: A total of 100 stable intramural neonates weighing between 1000 and 1499 g and gestational age less than 34 weeks were randomly allocated to enteral feeding (expressed human milk or formula) advancement of 20 mL/kg/day (n = 50) or 30 mL/kg/day (n = 50).
RESULTS: Neonates in the rapid feeding advancement group achieved full volume feedings before the slow advancement group (median 7 days vs. 9 days) (p < 0.001), had significantly fewer days of intravenous fluids (median 2 days vs. 3.4 days) (p < 0.001), shorter length of stay in hospital (median 9.5 days vs. 11 days) (p = 0.003) and regained birth weight earlier (median 16 days vs. 22 days) (p < 0.001). There were no statistical differences in the proportion of infants with apnea, feed interruption or feed intolerance.
CONCLUSION: Rapid enteral feeding advancements of 30 mL/kg/day are well tolerated by stable preterm neonates weighing 1000-1499 g.
Sriram Krishnamurthy; Piyush Gupta; Sanjib Debnath; Sunil Gomber
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  99     ISSN:  1651-2227     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-16     Completed Date:  2010-01-28     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  42-6     Citation Subset:  IM    
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MeSH Terms
Chi-Square Distribution
Enteral Nutrition / adverse effects,  methods*
Enterocolitis, Necrotizing / etiology
Infant Formula / statistics & numerical data
Infant Nutritional Physiological Phenomena*
Infant, Newborn
Infant, Premature / physiology*
Infant, Very Low Birth Weight / physiology*
Length of Stay
Milk, Human
Statistics, Nonparametric
Time Factors
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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