Document Detail

Slow-transit Constipation.
MedLine Citation:
PMID:  11469989     Owner:  NLM     Status:  Publisher    
Idiopathic slow-transit constipation is a clinical syndrome predominantly affecting women, characterized by intractable constipation and delayed colonic transit. This syndrome is attributed to disordered colonic motor function. The disorder spans a spectrum of variable severity, ranging from patients who have relatively mild delays in transit but are otherwise indistinguishable from irritable bowel syndrome to patients with colonic inertia or chronic megacolon. The diagnosis is made after excluding colonic obstruction, metabolic disorders (hypothyroidism, hypercalcemia), drug-induced constipation, and pelvic floor dysfunction (as discussed by Wald ). Most patients are treated with one or more pharmacologic agents, including dietary fiber supplementation, saline laxatives (milk of magnesia), osmotic agents (lactulose, sorbitol, and polyethylene glycol 3350), and stimulant laxatives (bisacodyl and glycerol). A subtotal colectomy is effective and occasionally is indicated for patients with medically refractory, severe slow-transit constipation, provided pelvic floor dysfunction has been excluded or treated.
Adil E. Bharucha; Sidney F. Philips
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Publication Detail:
Journal Detail:
Title:  Current treatment options in gastroenterology     Volume:  4     ISSN:  1534-309X     ISO Abbreviation:  Curr Treat Options Gastroenterol     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-Jul-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9815941     Medline TA:  Curr Treat Options Gastroenterol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  309-315     Citation Subset:  -    
Gastroenterology Research Unit and Enteric Neurosciences Program, Mayo Clinic, 200 First Street, SW, Rochester, MN 55905, USA.
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