Document Detail


Slow and steady is the key to beta-cell replication.
MedLine Citation:
PMID:  19379145     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The beta-cells of the pancreas are responsible for insulin production and their destruction results in type I diabetes. beta-cell maintenance, growth and regenerative repair is thought to occur predominately, if not exclusively, through the replication of existing beta-cells, not via an adult stem cell. It was recently found that all beta-cells contribute equally to islet growth and maintenance. The fact that all beta-cells replicate homogeneously makes it possible to set up straightforward screens for factors that increase beta-cell replication either In vitro or in vivo. It is possible that a circulating factor may be capable of increasing beta-cell replication or that intrinsic cell cycle regulators may affect beta-cell growth. An improved understanding of the in vivo maintenance and growth of beta-cells will facilitate efforts to expand beta-cells In vitro and may lead to new treatments for diabetes.
Authors:
Kristen Brennand; Doug Melton
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of cellular and molecular medicine     Volume:  13     ISSN:  1582-4934     ISO Abbreviation:  J. Cell. Mol. Med.     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-04-21     Completed Date:  2009-08-04     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  101083777     Medline TA:  J Cell Mol Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  472-87     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aging / metabolism
Animals
Bone Marrow Cells / cytology
Cell Differentiation
Cell Division*
Humans
Insulin-Secreting Cells / cytology*
Stem Cells / cytology
Grant Support
ID/Acronym/Agency:
U01 DK072505/DK/NIDDK NIH HHS; U01 DK072505-05/DK/NIDDK NIH HHS; //Howard Hughes Medical Institute
Comments/Corrections

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