| Slow, programmed maturation of the immunoglobulin HCDR3 repertoire during the third trimester of fetal life. | |
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MedLine Citation:
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PMID: 11675347 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The mean distribution of lengths in the third complementarity-determining region of the heavy chain (HCDR3) serves as a measure of the development of the antibody repertoire during ontogeny. To determine the timing and pattern of HCDR3 length maturation during the third trimester of pregnancy, the mean distribution of HCDR3 lengths among variable-diversity-joining-constant-mu (VDJC(mu)) transcripts from the cord blood was analyzed from 138 infants of 23 to 40 weeks' gestation, including 3 sets of twins, 2 of which were of dizygotic origin. HCDR3 maturation begins at the start of the third trimester; follows a slow, continuous expansion over a 5-month period; and is unaffected by race or sex. The range and mean distribution of lengths may vary in dizygotic twins, indicating individual rates of development. The mean HCDR3 length distribution in 10 premature infants with documented bacterial sepsis was then followed for 2 to 12 weeks after their first positive blood culture. HCDR3 spectrotype analysis demonstrated oligoclonal B-cell activation and expansion after sepsis, but maturation of the repertoire was not accelerated even by the systemic exposure to external antigen represented by bacteremia. Antibody repertoire development appears to be endogenously controlled and adheres to an individualized developmental progression that probably contributes to the relative immaturity of the neonatal immune response. |
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Authors:
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H W Schroeder; L Zhang; J B Philips |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Blood Volume: 98 ISSN: 0006-4971 ISO Abbreviation: Blood Publication Date: 2001 Nov |
Date Detail:
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Created Date: 2001-10-24 Completed Date: 2001-12-07 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7603509 Medline TA: Blood Country: United States |
Other Details:
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Languages: eng Pagination: 2745-51 Citation Subset: AIM; IM |
Affiliation:
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Division of Developmental and Clinical Immunology, Department of Medicine, University of Alabama at Birmingham, 35294, USA. harry.schroeder@cc.uab.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antibody Diversity
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immunology Complementarity Determining Regions / genetics, physiology* Cross Infection / immunology Female Fetal Blood / immunology Fetus / immunology* Gestational Age Humans Immune System / embryology Immunoglobulin Joining Region / genetics Immunoglobulin Variable Region / genetics Immunoglobulin mu-Chains / genetics Infant, Newborn Infant, Premature Male Pregnancy Pregnancy Trimester, Third RNA, Messenger / blood Time Factors Twins, Dizygotic |
| Grant Support | |
ID/Acronym/Agency:
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HD36292/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Complementarity Determining Regions; 0/Immunoglobulin Joining Region; 0/Immunoglobulin Variable Region; 0/Immunoglobulin mu-Chains; 0/RNA, Messenger |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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