Document Detail

'Slow pressor' hypertension from low-dose chronic angiotensin II infusion.
MedLine Citation:
PMID:  11903310     Owner:  NLM     Status:  MEDLINE    
1. Angiotensin (Ang) II causes growth-related effects on vascular smooth muscle cells in vitro and in vivo. 2. Chronic infusions of AngII systemically, at doses that are initially subpressor, result in slowly progressive increases in arterial pressure ('slow-pressor' hypertension). It has been suggested that the hypertension is due to induced growth in systemic resistance vessel walls by the AngII infusions. 3. We report the results of several studies investigating whether there are also induced structural changes in renal resistance vessels during chronic AngII infusions. We have developed models in Sprague-Dawley rats in which low-dose AngII infusions, either into the renal artery (thus restricting the effects to the kidney) or systemically, result in hypertension. 5. In both models, we have evidence suggesting that chronic AngII infusions have resulted in apparent structurally induced reductions in renal vasculature lumen upstream to the glomerulus. 6. The role of these renal changes in the development of the hypertension remain to be determined.
A Edgley; M Kett; W Anderson
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  28     ISSN:  0305-1870     ISO Abbreviation:  Clin. Exp. Pharmacol. Physiol.     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2002-03-20     Completed Date:  2002-08-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  1035-9     Citation Subset:  IM    
Department of Physiology, Monash University, Victoria, Australia.
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MeSH Terms
Angiotensin II / administration & dosage*,  pharmacology*
Blood Pressure / drug effects*,  physiology
Blood Vessels / drug effects,  pathology
Endothelium, Vascular / drug effects*,  physiology*
Hypertension, Renovascular / chemically induced*,  physiopathology
Kidney / drug effects,  pathology
Models, Cardiovascular
Muscle, Smooth, Vascular / drug effects,  physiology
Rats, Sprague-Dawley
Renal Artery Obstruction / physiopathology
Renal Circulation / drug effects
Reg. No./Substance:
11128-99-7/Angiotensin II

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