| Slow fluid infusion alters esophageal tone before onset of esophageal contraction in humans. | |
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MedLine Citation:
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PMID: 11855538 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated whether esophageal tone was altered by fluid infusion before the onset of esophageal contraction. In nine healthy volunteers, intraluminal esophageal pressure and esophageal pH were measured with a three-channel solid-state transducer and microglass electrodes, respectively. Saline or 0.1 N hydrochloric acid was infused at 0.25 ml/sec 5 cm above the lower esophageal sphincter. The effect of atropine (80 microg/kg, intravenously) was also studied. Infusion of either saline or hydrochloric acid suddenly increased the midesophageal intraluminal pressure (8.2-8.4 mm Hg) and decreased the pressure more distally (8.0-8.5 mm Hg) with a latency of 23 sec. There were no significant differences between the effects of saline and hydrochloric acid. Atropine significantly (P < 0.05) lessened the midesophageal increase in pressure, but only slightly inhibited the distal decrease. Atropine did not alter the latency. Esophageal tone was altered by slow fluid infusion. This previously unknown physiological response may be a mechanism for storing liquid in the esophageal body until the start of contractions for clearance. |
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Authors:
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Motoyasu Kusano; Masaki Maeda; Keiko Minashi; Sayaka Tomizawa; Yasuyuki Shimoyama; Osamu Kawamura; Masatomo Mori |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Digestive diseases and sciences Volume: 47 ISSN: 0163-2116 ISO Abbreviation: Dig. Dis. Sci. Publication Date: 2002 Feb |
Date Detail:
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Created Date: 2002-02-21 Completed Date: 2002-03-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7902782 Medline TA: Dig Dis Sci Country: United States |
Other Details:
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Languages: eng Pagination: 251-5 Citation Subset: AIM; IM |
Affiliation:
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Department of Endoscopy and Endoscopic Surgery, Gunma University Hospital, Maebashi, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Atropine / diagnostic use Esophagogastric Junction / drug effects, physiology Esophagus / drug effects, physiology* Female Humans Hydrochloric Acid / diagnostic use Hydrogen-Ion Concentration Isotonic Solutions / diagnostic use Male Manometry Muscle Contraction / drug effects Muscle, Smooth / drug effects, physiology Peristalsis / drug effects, physiology Pressure Sodium Chloride / diagnostic use |
| Chemical | |
Reg. No./Substance:
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0/Isotonic Solutions; 51-55-8/Atropine; 7647-01-0/Hydrochloric Acid; 7647-14-5/Sodium Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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