Document Detail

Slow fluid infusion alters esophageal tone before onset of esophageal contraction in humans.
MedLine Citation:
PMID:  11855538     Owner:  NLM     Status:  MEDLINE    
We investigated whether esophageal tone was altered by fluid infusion before the onset of esophageal contraction. In nine healthy volunteers, intraluminal esophageal pressure and esophageal pH were measured with a three-channel solid-state transducer and microglass electrodes, respectively. Saline or 0.1 N hydrochloric acid was infused at 0.25 ml/sec 5 cm above the lower esophageal sphincter. The effect of atropine (80 microg/kg, intravenously) was also studied. Infusion of either saline or hydrochloric acid suddenly increased the midesophageal intraluminal pressure (8.2-8.4 mm Hg) and decreased the pressure more distally (8.0-8.5 mm Hg) with a latency of 23 sec. There were no significant differences between the effects of saline and hydrochloric acid. Atropine significantly (P < 0.05) lessened the midesophageal increase in pressure, but only slightly inhibited the distal decrease. Atropine did not alter the latency. Esophageal tone was altered by slow fluid infusion. This previously unknown physiological response may be a mechanism for storing liquid in the esophageal body until the start of contractions for clearance.
Motoyasu Kusano; Masaki Maeda; Keiko Minashi; Sayaka Tomizawa; Yasuyuki Shimoyama; Osamu Kawamura; Masatomo Mori
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  47     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-02-21     Completed Date:  2002-03-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  251-5     Citation Subset:  AIM; IM    
Department of Endoscopy and Endoscopic Surgery, Gunma University Hospital, Maebashi, Japan.
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MeSH Terms
Atropine / diagnostic use
Esophagogastric Junction / drug effects,  physiology
Esophagus / drug effects,  physiology*
Hydrochloric Acid / diagnostic use
Hydrogen-Ion Concentration
Isotonic Solutions / diagnostic use
Muscle Contraction / drug effects
Muscle, Smooth / drug effects,  physiology
Peristalsis / drug effects,  physiology
Sodium Chloride / diagnostic use
Reg. No./Substance:
0/Isotonic Solutions; 51-55-8/Atropine; 7647-01-0/Hydrochloric Acid; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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