| Slow enlargement of choroidal nevi: a long-term follow-up study. | |
| | |
MedLine Citation:
|
PMID: 20801518 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
PURPOSE: Choroidal nevi are generally considered to be stable lesions, and growth of a choroidal nevus is usually believed to be a sign of malignant transformation. We performed this study to determine whether choroidal nevi enlarge over a long period of follow-up without undergoing malignant transformation. DESIGN: Retrospective observational case series. PARTICIPANTS: A total of 278 patients with 284 nevi who had at least 7 years of photographic follow-up without clinical signs of transformation into melanoma were included in the study. METHODS: Data on demographic and clinical information were extracted from patients' charts. Detailed fundus drawings and color fundus photographs were reviewed and compared for evidence of enlargement. MAIN OUTCOME MEASURES: Nevus enlargement without clinical evidence of transformation into melanoma. RESULTS: Of the 278 patients, 69% were female and more than 99% were White with a median age at presentation of 57 years (range, 4-87 years). The largest nevus basal diameter was a median of 5 mm (range, 0.5-14 mm), and the median thickness was 1.5 mm (range, 0.1-3.6 mm). Only 14 nevi (5%) had subretinal fluid outside the nevus, and 6% showed overlying orange pigment. Overlying retinal pigment epithelial alterations included drusen (61%), atrophy (6%), hyperplasia (10%), and fibrous metaplasia (6%). Of 284 nevi, 31% showed slight enlargement over a mean follow-up of 15 years. The median increase in diameter was 1 mm (mean, 0.9 mm; range, 0.2-3.0 mm), and the median rate of enlargement was 0.06 mm/yr (mean, 0.06 mm/yr; range, 0.01-0.36 mm/yr). None of the lesions that enlarged developed new risk factors that are generally associated with malignant transformation. Frequency of enlargement was 54% in patients aged less than 40 years and 19% in patients aged more than 60 years. On multivariate analysis, younger patient age was the only factor predictive of nevus enlargement (P<0.001). CONCLUSIONS: With long-term follow up, 31% of choroidal nevi showed slight enlargement without clinical evidence of transformation into melanoma. The frequency of enlargement was inversely related to patient age. FINANCIAL DISCLOSURE(S): The author(s) have no proprietary or commercial interest in any materials discussed in this article. |
| | |
Authors:
|
Arman Mashayekhi; Sophia Siu; Carol L Shields; Jerry A Shields |
Related Documents
:
|
16946758 - Comparison of visual acuity outcomes in predominantly classic vs occult lesions in age-... 12441718 - Treatment of subfoveal choroidal neovascularization associated with multifocal choroidi... 16082398 - Low power vs standard power transpupillary thermotherapy in patients with age-related m... 17803438 - Short-term results of intravitreal bevacizumab for macular edema with retinal vein obst... 16049238 - Hydroxyapatite-ceramic-coated femoral stems in revision hip surgery. 2469588 - Preoperative prediction of results of prostatectomy by a symptom score and radionuclide... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Ophthalmology Volume: 118 ISSN: 1549-4713 ISO Abbreviation: Ophthalmology Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-02-04 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7802443 Medline TA: Ophthalmology Country: United States |
Other Details:
|
Languages: eng Pagination: 382-8 Citation Subset: IM |
Copyright Information:
|
Copyright © 2011 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved. |
Affiliation:
|
Ocular Oncology Service, Wills Eye Institute, Thomas Jefferson University, Philadelphia, Pennsylvania. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Spectral transmittance of intraocular lenses under natural and artificial illumination: criteria ana...
Next Document: The concave iris in pigment dispersion syndrome.