| Slightly elevated B-type natriuretic peptide levels in a non-heart failure range indicate a worse left ventricular diastolic function in individuals with, as compared with individuals without, type 2 diabetes: the Hoorn Study. | |
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MedLine Citation:
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PMID: 20667891 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: Higher plasma B-type natriuretic peptide (BNP) in a non-heart failure (HF) range predicts HF and cardiovascular disease (CVD) mortality in the general population. Heart failure is highly prevalent in type 2 diabetes mellitus (T2DM), but associations of BNP to left ventricular (LV) mass and function in individuals with a different glucose status have not been compared. We therefore aimed to explore (i) the association of BNP levels in a non-HF range with structural and functional markers of LV function, and (ii) possible effect modification by glucose tolerance categories. METHODS AND RESULTS: Linear regression analyses were performed to investigate associations of BNP with 2D echocardiographic measures of LV mass index, LV systolic function, and markers of LV diastolic function in a population-based study of men and women with normal glucose metabolism (NGM, n = 197), impaired glucose metabolism (IGM, n = 128), or T2DM (n = 204). Patients were aged between 50 and 87 years, had BNP levels below 50 pmol/L, and no LV wall motion abnormalities. B-type natriuretic peptide levels ranged from 0.4 to 46.1 pmol/L, the median was 4.2 pmol/L. Higher BNP was significantly associated with increased LV mass and deteriorated LV diastolic function, but not with LV systolic function. B-type natriuretic peptide was more strongly associated with LV diastolic function in T2DM compared with NGM and IGM. CONCLUSION: B-type natriuretic peptide was associated with LV mass and markers of LV diastolic function, and the association of BNP with the latter appeared to be particularly strong in individuals with T2DM. This implies that the presence or absence of T2DM should be taken into account if BNP levels are used to assess CVD risk. |
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Authors:
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Katja van den Hurk; Marjan Alssema; Otto Kamp; Ronald M Henry; Coen D Stehouwer; Michaela Diamant; Frans Boomsma; Rob J Heine; Giel Nijpels; Walter J Paulus; Jacqueline M Dekker |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-28 |
Journal Detail:
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Title: European journal of heart failure Volume: 12 ISSN: 1879-0844 ISO Abbreviation: Eur. J. Heart Fail. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-23 Completed Date: 2011-01-11 Revised Date: 2011-06-08 |
Medline Journal Info:
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Nlm Unique ID: 100887595 Medline TA: Eur J Heart Fail Country: Netherlands |
Other Details:
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Languages: eng Pagination: 958-65 Citation Subset: IM |
Affiliation:
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Department of Epidemiology and Biostatistics and the EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands. katja.vandenhurk@vumc.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Biological Markers / blood Cross-Sectional Studies Diabetes Mellitus, Type 2 / blood*, complications, physiopathology Diastole Disease Progression Female Heart Failure / blood*, complications, physiopathology Humans Immunoradiometric Assay Male Middle Aged Natriuretic Peptide, Brain / blood* Prevalence Prognosis Retrospective Studies Ventricular Dysfunction, Left / blood*, epidemiology, etiology Ventricular Function, Left / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 114471-18-0/Natriuretic Peptide, Brain |
| Comments/Corrections | |
Comment In:
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Eur J Heart Fail. 2010 Sep;12(9):898-900
[PMID:
20729373
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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