| Sleep-wake mechanisms and drug discovery: sleep EEG as a tool for the development of CNS-acting drugs. | |
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MedLine Citation:
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PMID: 22034388 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Sleep laboratory investigations constitute a unique noninvasive tool to analyze brain functioning, Polysomnographic recordings, even in the very early phase of development in humans, are mandatory in a developmental plan of a new sleep-acting compound. Sleep is also an interesting tool for the development of other drugs acting on the central nervous system (CNS), Indeed, changes in sleep electroencephalographic (EEG) characteristics are a very sensitive indication of the objective central effects of psychoactive drugs, and these changes are specific to the way the drug acts on the brain neurotransmitter systems. Moreover, new compounds can be compared with reference drugs in terms of the sleep EEG profile they induce. For instance, cognitive enhancers involving cholinergic mechanism have been consistently demonstrated to increase rapid eye movement (REM) sleep pressure, and studying drug-induced slow wave sleep (SWS) alteration is a particularly useful tool for the development of CNS compounds acting at the 5-HT(2A/C) receptor, such as most atypical antipsychotics and some antidepressant drugs. The sleep EEG profile of antidepressants, and particularly their effects on REM sleep, are specific to their ability to enhance noradrenergic or serotonergic transmission, it is suggested that the effects of noradrenergic versus serotonergic reuptake inhibition could be disentangled using specific monoamine depletion tests and by studying drug effects on sleep microsiructure. |
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Authors:
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Luc Staner |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Dialogues in clinical neuroscience Volume: 4 ISSN: 1294-8322 ISO Abbreviation: Dialogues Clin Neurosci Publication Date: 2002 Dec |
Date Detail:
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Created Date: 2011-10-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101238198 Medline TA: Dialogues Clin Neurosci Country: France |
Other Details:
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Languages: eng Pagination: 342-50 Citation Subset: - |
Affiliation:
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FORENAP, Institute for Research in Neuroscience and Neuropsychiatry, Rouffach, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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