| Sleep restriction during pregnancy: hypertension and renal abnormalities in young offspring rats. | |
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MedLine Citation:
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PMID: 21061858 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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STUDY OBJECTIVES: Because the maternal environment can affect several physiological functions of the newborn, the aim of the present study was to examine the impact of sleep restriction during pregnancy on renal morphology and function in young offspring. DESIGN: Female 3-month-old Wistar rats were divided in 2 experimental groups: C (control) and SR (sleep restriction between the 14th and 20th day of pregnancy). Pregnancy was confirmed by vaginal smear. SR females were subjected to sleep restriction by the multiple platform technique for 20 h daily. After birth, only male litters (6 for each mother) were selected and designated OC (offspring from C) and OSR (offspring from SR). At 2 months of age, blood pressure (BP) was measured by tail plethysmography; at 3 months the renal plasma flow (RPF), glomerular filtration rate (GFR), glomerular area, and number of glomeruli per mm3 were evaluated. MEASUREMENTS AND RESULTS: Offspring from SR had higher systolic blood pressure than OC. In this group (OSR), we also observed significant increase in RPF and GFR, enlarged glomeruli diameter, and reduced number of glomeruli per mm3 of renal tissue. CONCLUSIONS: Our data suggest that sleep restriction during pregnancy is able to modify renal development, resulting in morphologic and functional alterations in young offspring. |
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Authors:
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Janaina Thais Thomal; Beatriz Duarte Palma; Beatriz Felice Ponzio; Maria do Carmo Pinho Franco; Frida Zaladek-Gil; Zuleica Bruno Fortes; Sergio Tufik; Guiomar Nascimento Gomes |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Sleep Volume: 33 ISSN: 0161-8105 ISO Abbreviation: Sleep Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-11-10 Completed Date: 2010-12-14 Revised Date: 2011-07-27 |
Medline Journal Info:
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Nlm Unique ID: 7809084 Medline TA: Sleep Country: United States |
Other Details:
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Languages: eng Pagination: 1357-62 Citation Subset: IM |
Affiliation:
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Department of Physiology, Universidade Federal de São Paulo, São Paulo, Brazil. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Animals, Newborn Blood Pressure Body Weight Female Glomerular Filtration Rate Glucose Tolerance Test / methods, statistics & numerical data Hypertension / etiology*, physiopathology Kidney Diseases / etiology*, physiopathology Organ Size Pregnancy Pregnancy Complications* Prenatal Exposure Delayed Effects / etiology*, physiopathology Rats Rats, Wistar Sleep Deprivation / complications* |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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