Document Detail

Sleep quality, social well-being, gender, and inflammation: an integrative analysis in a national sample.
MedLine Citation:
PMID:  21884159     Owner:  NLM     Status:  MEDLINE    
Social isolation and poor sleep quality are independent predictors of poor health outcomes and increased biological risk for disease. We previously found in a small sample of older women that the presence of social ties compensated for poor sleep in associations with the inflammatory protein interleukin 6 (IL-6). The current study extended those findings to a national sample of middle-aged and older men and women. Using both subjective and objective sleep assessments, we found that in men, but not in women, social engagement moderated the association of subjective sleep complaints with both IL-6 and the soluble adhesion molecule E-selectin. Social engagement also moderated the link between sleep efficiency-assessed by actigraphy-and IL-6 levels in men, but not in women. These results extend our previous work and bolster the suggestion that positive psychological functioning may compensate for other risk factors in predicting advantageous profiles of biological risk in aging adults.
Elliot M Friedman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Twin Study    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  1231     ISSN:  1749-6632     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-09-02     Completed Date:  2011-11-10     Revised Date:  2014-09-05    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  23-34     Citation Subset:  IM    
Copyright Information:
© 2011 New York Academy of Sciences.
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MeSH Terms
E-Selectin / blood
Health Status
Inflammation / blood,  psychology*
Interleukin-6 / blood
Interpersonal Relations
Middle Aged
Personal Satisfaction*
Risk Factors
Sex Factors
Sleep / physiology*
Social Behavior*
Twins / psychology
Grant Support
1UL1RR025011/RR/NCRR NIH HHS; K01 AG029381/AG/NIA NIH HHS; K01 AG029381-04/AG/NIA NIH HHS; K01-AG029381/AG/NIA NIH HHS; M01-RR00865/RR/NCRR NIH HHS; M01-RR023942/RR/NCRR NIH HHS; P01-AG020166/AG/NIA NIH HHS
Reg. No./Substance:
0/E-Selectin; 0/Interleukin-6

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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