| Sleep propensity at daytime as assessed by Multiple Sleep Latency Tests (MSLT) in patients with schizophrenia increases with clozapine and olanzapine. | |
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MedLine Citation:
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PMID: 22257975 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sleep propensity at daytime has not been investigated in untreated patients with schizophrenia. Furthermore, while the antipsychotics clozapine and olanzapine are considered to frequently cause 'sleepiness' or 'sedation', this has not been objectified yet. Therefore, 30 patients with schizophrenia were included in this randomized, double-blind study. Sleep propensity was assessed before and after 2, 4 and 6 weeks of treatment with either clozapine or olanzapine using a Multiple Sleep Latency Test (MSLT); in the MSLT, sleep latencies of 5 nap opportunities of 20 min during daytime are averaged. In addition, the number of sleep onsets was recorded. Mean sleep latency in untreated schizophrenic patients was 16.2 ± 0.8 min at baseline. Both antipsychotics induced an increase of sleep propensity as indicated by a shortened sleep latency and more sleep onsets during the treatment period as compared to baseline. These effects were strongest in the morning. Four patients receiving clozapine and 3 patients receiving olanzapine reported subjective sleepiness, in all but one commencing in the first treatment week and persisting until study end. While the mean sleep latency during treatment was significantly shorter in these patients (12.3 ± 0.8 min) than in those without subjective sleepiness (14.9 ± 0.7 min), a short sleep latency was not necessarily associated with subjective sleepiness. In conclusion, mean sleep latency was >36% longer (i.e. sleep propensity was lower) in untreated patients with schizophrenia than in healthy subjects previously consistently reported. Furthermore, clozapine and olanzapine increased sleep propensity in schizophrenic patients. A minority of patients reported subjective sleepiness. |
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Authors:
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Michael Kluge; Hubertus Himmerich; Peter M Wehmeier; Christine Rummel-Kluge; Mira Dalal; Dunja Hinze-Selch; Thomas Kraus; Ralf W Dittmann; Thomas Pollmächer; Andreas Schuld |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2012-01-16 |
Journal Detail:
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Title: Schizophrenia research Volume: 135 ISSN: 1573-2509 ISO Abbreviation: Schizophr. Res. Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-02-24 Completed Date: 2012-06-26 Revised Date: 2012-08-22 |
Medline Journal Info:
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Nlm Unique ID: 8804207 Medline TA: Schizophr Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 123-7 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Psychiatry and Psychotherapy, University of Leipzig, Leipzig, Germany. Michael.Kluge@medizin.uni-leipzig.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Analysis of Variance Antipsychotic Agents / therapeutic use* Benzodiazepines / therapeutic use* Clozapine / therapeutic use* Disorders of Excessive Somnolence / drug therapy*, etiology Double-Blind Method Female Humans Male Middle Aged Polysomnography Psychiatric Status Rating Scales Reaction Time / drug effects Schizophrenia / complications, drug therapy* Sleep Stages / drug effects Statistics as Topic Time Factors Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Antipsychotic Agents; 12794-10-4/Benzodiazepines; 132539-06-1/olanzapine; 5786-21-0/Clozapine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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