| Sleep-predominant lowering of ambulatory blood pressure by bedtime inhalation of a novel muscarinic M3 receptor antagonist: a new "bronchoantihypertensive" strategy targeting the lung in hypertension with chronic obstructive pulmonary disease. | |
| | |
MedLine Citation:
|
PMID: 18633194 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Bedtime inhalation of a novel muscarinic M3 receptor antagonist markedly lowered ambulatory blood pressure (ABP), predominantly during sleep, in a chronic obstructive pulmonary disease (COPD) patient with masked nocturnal hypertension. This is the first case demonstrating that a bronchodilator significantly lowered ABP in a COPD patient with hypertension. This case suggests that bronchodilator therapy may have potential as a new antihypertensive strategy targeting the lung in hypertensive patients with impaired lung function. This "bronchoantihypertensive" therapy seems to be more effective for reducing sleep blood pressure in hypertensive patients with COPD and sleep hypoventilatory/hypoxemic syndromes. |
| | |
Authors:
|
Kazuomi Kario; Hideyuki Uno; Kazuyuki Shimada |
Related Documents
:
|
14529234 - Blood pressure response to out-patient drug treatment of hypertension in 1973-1993 at k... 10234084 - Hypotension: a forgotten illness?. 73694 - Improvement of medication compliance in uncontrolled hypertension. 3543114 - Management of urgent hypertension: a comparison of oral treatment regimens in the emerg... 3746194 - Hydrostatic pressures in glomeruli and renal vasculature of the hagfish, eptatretus sto... 2165094 - Association between habitual coffee consumption and blood pressure levels. |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: Hypertension research : official journal of the Japanese Society of Hypertension Volume: 31 ISSN: 0916-9636 ISO Abbreviation: Hypertens. Res. Publication Date: 2008 Apr |
Date Detail:
|
Created Date: 2008-07-17 Completed Date: 2008-08-13 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9307690 Medline TA: Hypertens Res Country: Japan |
Other Details:
|
Languages: eng Pagination: 817-21 Citation Subset: IM |
Affiliation:
|
Division of Cardiovascular Medicine, Jichi Medical University School of Medicine, Shimotsuke, Japan. kkario@jichi.ac.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Inhalation Aged Antihypertensive Agents / administration & dosage Blood Pressure / drug effects* Blood Pressure Monitoring, Ambulatory Bronchodilator Agents / administration & dosage* Circadian Rhythm Humans Hypertension / diagnosis, drug therapy*, etiology Male Pulmonary Disease, Chronic Obstructive / complications, drug therapy* Receptor, Muscarinic M3 / antagonists & inhibitors* Scopolamine Derivatives / administration & dosage* Sleep |
| Chemical | |
Reg. No./Substance:
|
0/Antihypertensive Agents; 0/Bronchodilator Agents; 0/Receptor, Muscarinic M3; 0/Scopolamine Derivatives; 136310-93-5/tiotropium |
| Comments/Corrections | |
Comment In:
|
Hypertens Res. 2008 Apr;31(4):589-91
[PMID:
18633168
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effects of different levels of exercise volume on endothelium-dependent vasodilation: roles of nitri...
Next Document: Analytical method for carbamate pesticides in processed foods by LC/MS/MS