Document Detail


Sleep-predominant lowering of ambulatory blood pressure by bedtime inhalation of a novel muscarinic M3 receptor antagonist: a new "bronchoantihypertensive" strategy targeting the lung in hypertension with chronic obstructive pulmonary disease.
MedLine Citation:
PMID:  18633194     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bedtime inhalation of a novel muscarinic M3 receptor antagonist markedly lowered ambulatory blood pressure (ABP), predominantly during sleep, in a chronic obstructive pulmonary disease (COPD) patient with masked nocturnal hypertension. This is the first case demonstrating that a bronchodilator significantly lowered ABP in a COPD patient with hypertension. This case suggests that bronchodilator therapy may have potential as a new antihypertensive strategy targeting the lung in hypertensive patients with impaired lung function. This "bronchoantihypertensive" therapy seems to be more effective for reducing sleep blood pressure in hypertensive patients with COPD and sleep hypoventilatory/hypoxemic syndromes.
Authors:
Kazuomi Kario; Hideyuki Uno; Kazuyuki Shimada
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Hypertension research : official journal of the Japanese Society of Hypertension     Volume:  31     ISSN:  0916-9636     ISO Abbreviation:  Hypertens. Res.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-07-17     Completed Date:  2008-08-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9307690     Medline TA:  Hypertens Res     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  817-21     Citation Subset:  IM    
Affiliation:
Division of Cardiovascular Medicine, Jichi Medical University School of Medicine, Shimotsuke, Japan. kkario@jichi.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Administration, Inhalation
Aged
Antihypertensive Agents / administration & dosage
Blood Pressure / drug effects*
Blood Pressure Monitoring, Ambulatory
Bronchodilator Agents / administration & dosage*
Circadian Rhythm
Humans
Hypertension / diagnosis,  drug therapy*,  etiology
Male
Pulmonary Disease, Chronic Obstructive / complications,  drug therapy*
Receptor, Muscarinic M3 / antagonists & inhibitors*
Scopolamine Derivatives / administration & dosage*
Sleep
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 0/Bronchodilator Agents; 0/Receptor, Muscarinic M3; 0/Scopolamine Derivatives; 136310-93-5/tiotropium
Comments/Corrections
Comment In:
Hypertens Res. 2008 Apr;31(4):589-91   [PMID:  18633168 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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