Document Detail


Sleep patterns in patients with late onset partial epilepsy receiving chronic carbamazepine (CBZ) therapy.
MedLine Citation:
PMID:  2127255     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A night-time polygraphic sleep recording was performed in 14 patients with late onset partial epilepsy receiving chronic carbamazepine monotherapy. All patients had unstable nocturnal sleep patterns as indicated by significantly altered sleep continuity parameters compared with normal controls. Patients with poor seizure control tended to show greater alterations of sleep stability compared to patients in complete clinical remission but the difference failed to reach statistical significance. Epileptic patients also showed less REM sleep and longer REM latencies compared with normal controls, the most altered REM values being observed in patients with poor seizure control. These data confirm that polygraphic sleep alterations are seen in patients with symptomatic focal epilepsy and indicate that these abnormalities occur irrespective of seizure recurrence.
Authors:
R Manni; C A Galimberti; C Zucca; L Parietti; A Tartara
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Epilepsy research     Volume:  7     ISSN:  0920-1211     ISO Abbreviation:  Epilepsy Res.     Publication Date:    1990 Sep-Oct
Date Detail:
Created Date:  1991-04-08     Completed Date:  1991-04-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8703089     Medline TA:  Epilepsy Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  72-6     Citation Subset:  IM    
Affiliation:
Institute of Neurology C. Mondino, University of Pavia, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adult
Carbamazepine / therapeutic use*
Electroencephalography
Epilepsies, Partial / drug therapy,  physiopathology*
Female
Humans
Male
Sleep / physiology*
Sleep Stages
Chemical
Reg. No./Substance:
298-46-4/Carbamazepine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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