| Sleep-induced ventilatory dysfunction in Down's syndrome. | |
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MedLine Citation:
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PMID: 6444353 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Three patients with Down's syndrome demonstrated severe sleep-induced ventilatory failure characterized by Cheyne-Stokes respiration with superimposed obstruction of the upper airway. Anatomic otolaryngologic factors were present in two of the three patients, implicating both mechanical and CNS factors in the pathogenesis of this phenomenon. Administration of protriptyline hydrochloride elicited considerable improvement in one case. Occult sleep-related ventilatory failure may account for the previously unexplained tendency for pulmonary hypertension to develop in patients with Down's syndrome. |
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Authors:
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R W Clark; H S Schmidt; D E Schuller |
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1294643 - Endoscopic diagnosis and treatment of mirizzi's syndrome. 3752013 - Upper airway obstruction in infants with fetal alcohol syndrome. 2349013 - Cerebral infarct in patients with hemorrhagic shock and encephalopathy syndrome. |
Publication Detail:
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Type: Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Archives of internal medicine Volume: 140 ISSN: 0003-9926 ISO Abbreviation: Arch. Intern. Med. Publication Date: 1980 Jan |
Date Detail:
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Created Date: 1980-03-17 Completed Date: 1980-03-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372440 Medline TA: Arch Intern Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 45-50 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Airway Obstruction / etiology Braces Cheyne-Stokes Respiration / etiology Down Syndrome / complications* Humans Male Medroxyprogesterone / therapeutic use Posture Protriptyline / therapeutic use Sleep Apnea Syndromes / complications*, physiopathology, therapy Spirometry |
| Chemical | |
Reg. No./Substance:
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438-60-8/Protriptyline; 520-85-4/Medroxyprogesterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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