Document Detail

Sleep-induced ventilatory dysfunction in Down's syndrome.
MedLine Citation:
PMID:  6444353     Owner:  NLM     Status:  MEDLINE    
Three patients with Down's syndrome demonstrated severe sleep-induced ventilatory failure characterized by Cheyne-Stokes respiration with superimposed obstruction of the upper airway. Anatomic otolaryngologic factors were present in two of the three patients, implicating both mechanical and CNS factors in the pathogenesis of this phenomenon. Administration of protriptyline hydrochloride elicited considerable improvement in one case. Occult sleep-related ventilatory failure may account for the previously unexplained tendency for pulmonary hypertension to develop in patients with Down's syndrome.
R W Clark; H S Schmidt; D E Schuller
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of internal medicine     Volume:  140     ISSN:  0003-9926     ISO Abbreviation:  Arch. Intern. Med.     Publication Date:  1980 Jan 
Date Detail:
Created Date:  1980-03-17     Completed Date:  1980-03-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372440     Medline TA:  Arch Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  45-50     Citation Subset:  AIM; IM    
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MeSH Terms
Airway Obstruction / etiology
Cheyne-Stokes Respiration / etiology
Down Syndrome / complications*
Medroxyprogesterone / therapeutic use
Protriptyline / therapeutic use
Sleep Apnea Syndromes / complications*,  physiopathology,  therapy
Reg. No./Substance:
438-60-8/Protriptyline; 520-85-4/Medroxyprogesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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