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Sleep endoscopy with simulation bite for prediction of oral appliance treatment outcome.
MedLine Citation:
PMID:  23205856     Owner:  NLM     Status:  Publisher    
The aim of this study was to assess the value of drug-induced sleep endoscopy (DISE) using a custom-made simulation bite in maximal comfortable protrusion (MCP) of the mandible, in the prediction of treatment outcome for obstructive sleep apnoea (OSA) with a mandibular advancement device (MAD). Two hundred patients (74% male; age 46 ± 9 years; apnoea-hypopnoea index [AHI] 19 ± 13 h(-1) sleep; body mass index [BMI] 27 ± 4 kg m(-2) ) with sleep-disordered breathing underwent DISE with a simulation bite in MCP. One hundred and thirty-five patients with an established diagnosis of OSA commenced MAD treatment. The associations between the findings during DISE with simulation bite and treatment outcome were evaluated. Treatment response was defined as a reduction in AHI following MAD treatment of ≥ 50% compared to baseline. Overall MAD treatment response in the studied population was 69%. The results of this study demonstrated a statistically significant association between a positive effect of the simulation bite on the upper airway patency during DISE and treatment response with MAD (P < 0.01). The results of this study suggest that the use of a simulation bite in maximal comfortable protrusion (MCP) of the mandible, as used during DISE in patients with OSA, tends to be effective in predicting treatment response of MAD treatment.
Anneclaire V M T Vroegop; Olivier M Vanderveken; Marijke Dieltjens; Kristien Wouters; Vera Saldien; Marc J Braem; Paul H Van de Heyning
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-4
Journal Detail:
Title:  Journal of sleep research     Volume:  -     ISSN:  1365-2869     ISO Abbreviation:  J Sleep Res     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9214441     Medline TA:  J Sleep Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 European Sleep Research Society.
Departments of ENT, Head and Neck Surgery, Antwerp University Hospital, Edegem, Antwerp, Belgium; Faculty of Medicine and Health Sciences, University of Antwerp, Edegem, Antwerp, Belgium.
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