Document Detail

Sleep disturbance in euthymic bipolar patients.
MedLine Citation:
PMID:  21965189     Owner:  NLM     Status:  MEDLINE    
Sleep disturbance is a common feature during mood episodes in bipolar disorder. The aim of this study was to investigate the prevalence of such symptoms among euthymic bipolar patients, and their association with risk for mood episode recurrence. A cohort of bipolar I and II subjects participating in the Systematic Treatment Enhancement Program for Bipolar Disorder who were euthymic for at least 8 weeks were included in this analysis. Survival analysis was used to examine the association between sleep disturbance on the Montgomery-Asberg Depression Rating Scale (MADRS) and recurrence risk. A total of 73/483 bipolar I and II subjects reported at least mild sleep disturbance (MADRS sleep item ≥2) for the week prior to study entry. The presence of sleep problems was associated with a history of psychosis, number of previous suicide attempts, and anticonvulsant use. Sleep disturbance at study entry was significantly associated with risk for mood episode recurrence. Sleep disturbance is not uncommon between episodes for individuals with bipolar disorder and may be associated with a more severe course of illness. This suggests that sleep disturbance is an important prodromal symptom of bipolar disorder and should be considered a target for pharmacologic or psychosocial maintenance treatment.
Louisa G Sylvia; Jamie M Dupuy; Michael J Ostacher; Colleen M Cowperthwait; Aleena C Hay; Gary S Sachs; Andrew A Nierenberg; Roy H Perlis
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-09-29
Journal Detail:
Title:  Journal of psychopharmacology (Oxford, England)     Volume:  26     ISSN:  1461-7285     ISO Abbreviation:  J. Psychopharmacol. (Oxford)     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-18     Completed Date:  2012-12-14     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  8907828     Medline TA:  J Psychopharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1108-12     Citation Subset:  IM    
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MeSH Terms
Bipolar Disorder / complications,  drug therapy,  psychology*
Cohort Studies
Psychiatric Status Rating Scales / statistics & numerical data
Psychotic Disorders / complications,  psychology
Psychotropic Drugs / adverse effects
Sleep Initiation and Maintenance Disorders / complications,  psychology*
Suicide, Attempted / psychology
Grant Support
Reg. No./Substance:
0/Psychotropic Drugs

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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