| Sleep-disordered breathing and pregnancy: potential mechanisms and evidence for maternal and fetal morbidity. | |
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MedLine Citation:
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PMID: 20859210 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: This article reviews current data on pathophysiologic mechanisms by which sleep-disordered breathing during pregnancy may cause harm, and explores biological pathways for associated adverse maternal and fetal outcomes, especially pregnancy-induced hypertension and gestational diabetes. RECENT FINDINGS: Accumulating data indicate that snoring and sleep apnea during pregnancy are likely to increase the risk for gestational hypertension and preeclampsia. Several new studies have observed that sleep-disordered breathing and short sleep duration also increase the risk of gestational diabetes, similar to observations in the general population. There are varying levels of emerging evidence for potential mechanisms, including oxidative stress, increased sympathetic activity and inflammation, adipokine levels and insulin resistance, linking sleep-disordered breathing events during pregnancy to adverse outcomes. SUMMARY: Sleep-disordered breathing and adverse maternal-fetal outcomes such as preeclampsia and gestational diabetes share a number of mechanistic pathways, and growing data in pregnant women indicate that snoring and sleep apnea increase the risk of these and other complications for both the mother and the fetus. Nevertheless, direct evidence of the pathophysiologic mechanisms by which sleep-disordered breathing during pregnancy exerts negative effects remains sparse. |
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Authors:
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Bilgay Izci-Balserak; Grace W Pien |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current opinion in pulmonary medicine Volume: 16 ISSN: 1531-6971 ISO Abbreviation: Curr Opin Pulm Med Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-09-30 Completed Date: 2011-01-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9503765 Medline TA: Curr Opin Pulm Med Country: United States |
Other Details:
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Languages: eng Pagination: 574-82 Citation Subset: IM |
Affiliation:
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Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, 3624 Market Street, Philadelphia, PA 19104, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Diabetes, Gestational
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epidemiology Female Humans Pre-Eclampsia / epidemiology Pregnancy Pregnancy Complications / epidemiology* Pregnancy Outcome Risk Factors Sleep Apnea Syndromes / complications* Snoring / complications |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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