Document Detail

Sleep disordered breathing in medically stable patients with myasthenia gravis.
MedLine Citation:
PMID:  17355555     Owner:  NLM     Status:  MEDLINE    
We investigate sleep and breathing in clinically stable myasthenia gravis (MG) patients and ask weather sleep disordered breathing (SDB) is causally linked with MG. Nineteen MG patients with a mean disease duration of 9.7 years underwent sleep studies in two consecutive nights. The primary outcome measure was the respiratory disturbance index (RDI) in terms of snoring and apneas/hypopneas. Further outcome measurements were total sleep time, sleep stage distribution and the number of arousals. A clinically relevant SDB in terms of obstructive sleep apnea (OSA) (defined as RDI > 10/h) was found in four patients. There were only a few central apneas (central apnea index: 0.19 +/- 0.4/h). We did not find a relationship between maximum inspiratory pressure and SDB (r = -0.03). There is no evidence for a causal relationship between medically stable MG and SDB in terms of OSA. The extent of respiratory muscle weakness failed to correlate with SDB. Furthermore, our study does not confirm the high occurrence of central respiratory events during sleep in patients with well-controlled MG.
J Prudlo; J Koenig; S Ermert; J Juhász
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of neurology : the official journal of the European Federation of Neurological Societies     Volume:  14     ISSN:  1468-1331     ISO Abbreviation:  Eur. J. Neurol.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-03-14     Completed Date:  2007-05-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9506311     Medline TA:  Eur J Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  321-6     Citation Subset:  IM    
Neurologische Klinik, Universität des Saarlandes, Homburg/Saar, Germany.
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MeSH Terms
Middle Aged
Myasthenia Gravis / complications*,  physiopathology*
Respiratory Insufficiency / etiology,  physiopathology
Respiratory Muscles / physiopathology
Respiratory Physiological Phenomena
Sleep / physiology
Sleep Apnea Syndromes / diagnosis,  etiology*,  physiopathology*
Sleep Apnea, Obstructive / diagnosis,  etiology,  physiopathology

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