Document Detail

Sleep deprivation increases blood pressure in healthy normotensive elderly and attenuates the blood pressure response to orthostatic challenge.
MedLine Citation:
PMID:  21358850     Owner:  NLM     Status:  MEDLINE    
STUDY OBJECTIVES: To determine how aging affects the impact of sleep deprivation on blood pressure at rest and under orthostatic challenge.
DESIGN: Subjects underwent a night of sleep and 24.5 h of sleep deprivation in a crossover counterbalanced design.
SETTING: Sleep laboratory.
PARTICIPANTS: Sixteen healthy normotensive men and women: 8 young adults (mean 24 years [SD 3.1], range 20-28 years) and 8 elderly adults (mean 64.1 years [SD 3.4], range 60-69 years).
INTERVENTIONS: Sleep deprivation.
MEASUREMENTS AND RESULTS: Brachial cuff arterial blood pressure and heart rate were measured in semi-recumbent and upright positions. These measurements were compared across homeostatic sleep pressure conditions and age groups. Sleep deprivation induced a significant increase in systolic and diastolic blood pressure in elderly but not young adults. Moreover, sleep deprivation attenuated the systolic blood pressure orthostatic response in both age groups.
CONCLUSIONS: Our results suggest that sleep deprivation alters the regulatory mechanisms of blood pressure and might increase the risk of hypertension in healthy normotensive elderly.
Rébecca Robillard; Paola A Lanfranchi; François Prince; Daniel Filipini; Julie Carrier
Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2011-03-01
Journal Detail:
Title:  Sleep     Volume:  34     ISSN:  1550-9109     ISO Abbreviation:  Sleep     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-01     Completed Date:  2011-07-14     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  7809084     Medline TA:  Sleep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  335-9     Citation Subset:  IM    
Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Montréal, Canada.
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MeSH Terms
Age Factors
Blood Pressure / physiology*
Cross-Over Studies
Hypotension, Orthostatic / etiology,  physiopathology*
Middle Aged
Sleep / physiology
Sleep Deprivation / complications,  physiopathology*
Young Adult
Comment In:
Sleep. 2011 Mar;34(3):251-2   [PMID:  21358841 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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