| Sleep deprivation increases blood pressure in healthy normotensive elderly and attenuates the blood pressure response to orthostatic challenge. | |
| | |
MedLine Citation:
|
PMID: 21358850 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
STUDY OBJECTIVES: To determine how aging affects the impact of sleep deprivation on blood pressure at rest and under orthostatic challenge. DESIGN: Subjects underwent a night of sleep and 24.5 h of sleep deprivation in a crossover counterbalanced design. SETTING: Sleep laboratory. PARTICIPANTS: Sixteen healthy normotensive men and women: 8 young adults (mean 24 years [SD 3.1], range 20-28 years) and 8 elderly adults (mean 64.1 years [SD 3.4], range 60-69 years). INTERVENTIONS: Sleep deprivation. MEASUREMENTS AND RESULTS: Brachial cuff arterial blood pressure and heart rate were measured in semi-recumbent and upright positions. These measurements were compared across homeostatic sleep pressure conditions and age groups. Sleep deprivation induced a significant increase in systolic and diastolic blood pressure in elderly but not young adults. Moreover, sleep deprivation attenuated the systolic blood pressure orthostatic response in both age groups. CONCLUSIONS: Our results suggest that sleep deprivation alters the regulatory mechanisms of blood pressure and might increase the risk of hypertension in healthy normotensive elderly. |
| | |
Authors:
|
Rébecca Robillard; Paola A Lanfranchi; François Prince; Daniel Filipini; Julie Carrier |
Publication Detail:
|
Type: Clinical Trial; Journal Article Date: 2011-03-01 |
Journal Detail:
|
Title: Sleep Volume: 34 ISSN: 1550-9109 ISO Abbreviation: Sleep Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-03-01 Completed Date: 2011-07-14 Revised Date: 2011-09-13 |
Medline Journal Info:
|
Nlm Unique ID: 7809084 Medline TA: Sleep Country: United States |
Other Details:
|
Languages: eng Pagination: 335-9 Citation Subset: IM |
Affiliation:
|
Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Montréal, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Age Factors Aged Blood Pressure / physiology* Cross-Over Studies Female Humans Hypotension, Orthostatic / etiology, physiopathology* Male Middle Aged Sleep / physiology Sleep Deprivation / complications, physiopathology* Young Adult |
| Comments/Corrections | |
Comment In:
|
Sleep. 2011 Mar;34(3):251-2
[PMID:
21358841
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Topographic differences in the adolescent maturation of the slow wave EEG during NREM sleep.
Next Document: The dopamine transporter is decreased in the striatum of subjects with restless legs syndrome.