| Sleep deprivation in the rat: XVII. Effect of aspirin on elevated body temperature. | |
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MedLine Citation:
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PMID: 8506454 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Previous studies of total sleep deprivation (TSD) in the rat have shown an elevation of waking body temperature (Tb) early in the deprivation period. TSD rats defend this rise behaviorally by selecting warm ambient temperatures and autonomically by increasing heat production, thus indicating an elevation of thermoregulatory setpoint. Prostaglandins (PGs) can elevate setpoint and Tb. To investigate whether the TSD-induced rise in setpoint and Tb was mediated by PGs, aspirin, which blocks the synthesis of PGs, was administered 100 mg/kg s.q. to 11 TSD and 13 control (TSC) rats in baseline and deprivation. During baseline, aspirin produced a nonsignificant (0.16 degrees C) rise across all rats in waking Tb. For the sampled time period, waking Tb during deprivation day 3 was significantly elevated in TSD rats (0.64 degrees C, p < 0.01) but not in TSC rats (0.27 degrees C). Aspirin was administered on deprivation day 4. It produced a fall in waking Tb in TSD rats from its deprivation-induced elevation. The difference between the response to aspirin during baseline and during deprivation was significant (-0.25 degrees C, p < 0.05) for TSD rats but not TSC rats (-0.17 degrees C). Time awake after aspirin increased significantly (16.2%, p < 0.05) during baseline and declined nonsignificantly (1.1%) during deprivation. These data imply that at least part of the rise in Tb that is characteristic of TSD is mediated by PGs. To the extent that PGD2 promotes lower Tb and sleep in rats but PGE2 has opposite effects, the results are consistent with a shift from PGD2 predominance in baseline toward PGE2 predominance during TSD.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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B M Bergmann; C A Landis; C E Zenko; A Rechtschaffen |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Sleep Volume: 16 ISSN: 0161-8105 ISO Abbreviation: Sleep Publication Date: 1993 Apr |
Date Detail:
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Created Date: 1993-07-02 Completed Date: 1993-07-02 Revised Date: 2009-01-29 |
Medline Journal Info:
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Nlm Unique ID: 7809084 Medline TA: Sleep Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 221-5 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, University of Chicago, Illinois. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aspirin / pharmacology* Body Temperature / drug effects* Body Temperature Regulation / drug effects Male Prostaglandins / biosynthesis, physiology Rats Rats, Sprague-Dawley Sleep Deprivation* Wakefulness |
| Grant Support | |
ID/Acronym/Agency:
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MH18428/MH/NIMH NIH HHS; MH4151/MH/NIMH NIH HHS; T32 MH18825/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Prostaglandins; 50-78-2/Aspirin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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