| Sleep deprivation in the rat: XIX. Effects of thyroxine administration. | |
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MedLine Citation:
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PMID: 7676163 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chronic total sleep deprivation (TSD) in the rat produces an initial elevation and then declining body temperatures, increasing metabolic rate and eventual death. Because TSD rats will engage in warming behavior, one hypothesis is that the metabolic increase is an unsuccessful attempt at warming to combat a lethal hypothermia. However, TSD rats also undergo weight loss and progressive deterioration of skin and fur, suggesting TSD-induced pathological catabolic activity, possibly secondary to increased metabolic rate, that could be lethal. To evaluate these alternatives, the metabolic rate of rats was increased by thyroxine (T4) treatment while subjecting them to TSD. Compared to TSD rats not given T4, they had higher metabolic rates, higher body temperatures and reduced warming behavior, but their survival period was 37% shorter. Thus, it is unlikely that hypothermia is the cause of death in TSD rats. Weight and appearance declined more rapidly in T4-treated rats, but at the same proportions of survival time, skin pathology and decline in appearance were less evident in T4-treated rats than in TSD rats not given T4. Thus, there is some doubt whether a general pathological catabolic process is the cause of death. It is also possible that a specific morbid process normally reversed by sleep was accelerated by T4 administration. |
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Authors:
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B M Bergmann; M A Gilliland; S Balzano; S Refetoff; A Rechtschaffen |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Sleep Volume: 18 ISSN: 0161-8105 ISO Abbreviation: Sleep Publication Date: 1995 Jun |
Date Detail:
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Created Date: 1995-10-19 Completed Date: 1995-10-19 Revised Date: 2009-01-29 |
Medline Journal Info:
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Nlm Unique ID: 7809084 Medline TA: Sleep Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 317-24 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, University of Chicago, Illinois 60637-1891, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Behavior, Animal / drug effects Body Temperature / drug effects Body Weight / drug effects Electroencephalography Electromyography Feeding Behavior / drug effects Male Rats Rats, Sprague-Dawley* Sleep / drug effects Sleep Deprivation* Sleep, REM / drug effects Thyroxine / pharmacology* Weight Loss |
| Grant Support | |
ID/Acronym/Agency:
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DK-15070/DK/NIDDK NIH HHS; DK-42431/DK/NIDDK NIH HHS; MH-04151/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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7488-70-2/Thyroxine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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