Document Detail


Sleep deprivation amplifies striatal activation to monetary reward.
MedLine Citation:
PMID:  23286303     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Sleep loss produces abnormal increases in reward seeking but the mechanisms underlying this phenomenon are poorly understood. The present study examined the influence of one night of sleep deprivation on neural responses to a monetary reward task in a sample of late adolescents/young adults.
METHOD: Using a within-subjects crossover design, 27 healthy, right-handed late adolescents/young adults (16 females, 11 males; mean age 23.1 years) underwent functional magnetic resonance imaging (fMRI) following a night of sleep deprivation and following a night of normal sleep. Participants’ recent sleep history was monitored using actigraphy for 1 week prior to each sleep condition.
RESULTS: Following sleep deprivation, participants exhibited increased activity in the ventral striatum (VS) and reduced deactivation in the medial prefrontal cortex (mPFC) during the winning of monetary reward, relative to the same task following normal sleep conditions. Shorter total sleep time over the five nights before the sleep-deprived testing condition was associated with reduced deactivation in the mPFC during reward.
CONCLUSIONS: These findings support the hypothesis that sleep loss produces aberrant functioning in reward neural circuitry, increasing the salience of positively reinforcing stimuli. Aberrant reward functioning related to insufficient sleep may contribute to the development and maintenance of reward dysfunction-related disorders, such as compulsive gambling, eating, substance abuse and mood disorders.
Authors:
B C Mullin; M L Phillips; G J Siegle; D J Buysse; E E Forbes; P L Franzen
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2013-01-04
Journal Detail:
Title:  Psychological medicine     Volume:  43     ISSN:  1469-8978     ISO Abbreviation:  Psychol Med     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-08-30     Completed Date:  2014-04-22     Revised Date:  2014-10-14    
Medline Journal Info:
Nlm Unique ID:  1254142     Medline TA:  Psychol Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  2215-25     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Actigraphy
Adolescent
Adult
Corpus Striatum / physiology,  physiopathology*
Cross-Over Studies
Female
Functional Neuroimaging / instrumentation,  methods*
Humans
Magnetic Resonance Imaging
Male
Prefrontal Cortex / physiology,  physiopathology*
Reward*
Sleep / physiology*
Sleep Deprivation / physiopathology*
Young Adult
Grant Support
ID/Acronym/Agency:
K01 MH077106/MH/NIMH NIH HHS; K01 MH077106/MH/NIMH NIH HHS; R01 MH076961/MH/NIMH NIH HHS; R24 HL076852/HL/NHLBI NIH HHS; R24 HL076858/HL/NHLBI NIH HHS; T32 HL082610/HL/NHLBI NIH HHS; UL1 RR024153/RR/NCRR NIH HHS; UL1 RR024153/RR/NCRR NIH HHS
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