Document Detail

Sleep and cardiovascular disease.
MedLine Citation:
PMID:  16301095     Owner:  NLM     Status:  MEDLINE    
Sleep is an important modulator of cardiovascular function, both in physiological conditions and in disease states. In individuals without a primary sleep disorder, sleep may exert significant effects on the autonomic nervous system, systemic hemodynamics, cardiac function, endothelial function, and coagulation. Some of these influences can be directly linked to specific modulatory effects of sleep stages per se; others result from the natural circadian rhythm of various physiological processes. There is a temporal association between physiological sleep and occurrence of vascular events, cardiac arrhythmias, and sudden death. Epidemiological and pathophysiological studies also indicate that there may be a causal link between primary sleep abnormalities (sleep curtailment, shift work, and sleep-disordered breathing) and cardiovascular and metabolic disease, such as hypertension, atherosclerosis, stroke, heart failure, cardiac arrhythmias, sudden death, obesity, and the metabolic syndrome. Finally, sleep disturbances may occur as a result of several medical conditions (including obesity, chronic heart failure, and menopause) and may therefore contribute to cardiovascular morbidity associated with these conditions. Further understanding of specific pathophysiological pathways linking sleep disorders to cardiovascular disease is important for developing therapeutic strategies and may have important implications for cardiovascular chronotherapeutics.
Robert Wolk; Apoor S Gami; Arturo Garcia-Touchard; Virend K Somers
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current problems in cardiology     Volume:  30     ISSN:  0146-2806     ISO Abbreviation:  Curr Probl Cardiol     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-11-22     Completed Date:  2006-03-06     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7701802     Medline TA:  Curr Probl Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  625-62     Citation Subset:  IM    
Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
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MeSH Terms
Autonomic Nervous System / physiopathology
Cardiovascular Diseases / physiopathology*
Cardiovascular System / physiopathology*
Sleep / physiology*
Sleep Disorders / physiopathology*
Grant Support

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