| Sleep architecture in unrestrained rhesus monkeys (Macaca mulatta) synchronized to 24-hour light-dark cycles. | |
| | |
MedLine Citation:
|
PMID: 18788649 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
STUDY OBJECTIVES: To characterize the sleep patterns of unrestrained, diurnal nonhuman primates entrained to 24-hour light-dark cycles. DESIGN: EEG, EMG, and EOG were recorded continuously via implanted telemetry from 5 unrestrained male rhesus monkeys housed individually under a 16:8 light-dark cycle (LD 16:8; L = 13 lux; D = 0 lux). RESULTS: In a LD 16:8 cycle, all 5 monkeys demonstrated a long period of consolidated sleep during the 8-h dark period. On average, sleep accounted for 89.2% of the 8-h dark period and 25.2% of the 16-hour light period. REM sleep occupied 23% of total sleep time over 24 h, or 10.7% of the total time. The average length of the consolidated sleep (CS) period was 10.5 h, although the time of CS onset was variable. In contrast, the end of CS, and thus the onset of consolidated wakefulness (CW) demonstrated very little variation, typically occurring within 2 min of light onset. Ultradian NREM-REM cycles with periods of approximately 60 min were also observed. EEG delta activity during NREM sleep, thought to reflect the homeostatic sleep process, peaked at 3-4 h after CS onset. CONCLUSIONS: The present study demonstrates the feasibility of long-term, unrestrained sleep monitoring in nonhuman primates using fully-implantable biotelemetry. With minor exceptions, most notably a delay in peak delta activity, sleep-wake architecture, regulation, and consolidation in rhesus monkeys strongly resembles that of humans. These results demonstrate that the unrestrained rhesus monkey is an excellent biomedical model for human sleep. |
| | |
Authors:
|
Kung-Chiao Hsieh; Edward L Robinson; Charles A Fuller |
Related Documents
:
|
11152979 - Vocalization during episodes of prolonged expiration: a parasomnia related to rem sleep. 7173319 - Effects on sleep of phentolamine and epinephrine infused into the locus coeruleus of cats. 220429 - Women's vaginal responses during rem sleep. 3995119 - Behavioral responsivity during recovery sleep. 227029 - Amitriptyline and eeg sleep in depressed patients: i. drug effect. 8987799 - Pontine nitric oxide modulates acetylcholine release, rapid eye movement sleep generati... 11221549 - Peripheral retinal angioma presenting as macular pucker--case report. 3245269 - Cell movement and symmetry of the cellular environment. 21350389 - The effect of shift rotation on employee cortisol profile, sleep quality, fatigue, and ... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
|
Title: Sleep Volume: 31 ISSN: 0161-8105 ISO Abbreviation: Sleep Publication Date: 2008 Sep |
Date Detail:
|
Created Date: 2008-09-15 Completed Date: 2008-12-31 Revised Date: 2011-05-17 |
Medline Journal Info:
|
Nlm Unique ID: 7809084 Medline TA: Sleep Country: United States |
Other Details:
|
Languages: eng Pagination: 1239-50 Citation Subset: IM |
Affiliation:
|
Department of Neurobiology, Physiology & Behavior, University of California, Davis, CA 95616, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Circadian Rhythm / physiology* Computer Graphics Homeostasis / physiology Macaca mulatta / physiology* Male Polysomnography Reference Values Sleep / physiology* Sleep, REM / physiology Wakefulness / physiology |
| Grant Support | |
ID/Acronym/Agency:
|
RR00196/RR/NCRR NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Defining the boundaries of the response of sleep leg movements to a single dose of dopamine agonist.
Next Document: Effects of night work, sleep loss and time on task on simulated threat detection performance.