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Sleep apnea prevalence in acute myocardial infarction--the Sleep Apnea in Post-acute Myocardial Infarction Patients (SAPAMI) Study.
MedLine Citation:
PMID:  25064202     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
BACKGROUND: While sleep apnea (SA) might be a modifiable cardiovascular risk factor, recent data suggest that SA is severely underdiagnosed in patients after acute myocardial infarction (MI). There is limited evidence about day-night variation of onset of MI on dependence of having SA. We therefore investigated the prevalence of SA and examined the day-night variation of onset of MI in acute MI patients.
METHODS: We prospectively studied 782 consecutive patients admitted to the hospital with the diagnosis of acute MI. All subjects underwent sleep evaluations using a portable device after at least 48 h post-admission. Using the apnea-hypopnea index (AHI), groups were defined as patients without SA (<5 events/h), mild SA (5-15 events/h), moderate SA (15-30 events/h), and severe SA (≥ 30 events/h).
RESULTS: Almost all patients (98%) underwent urgent coronary angiography and 91% of patients underwent primary PCI. Using a threshold of AHI ≥ 5 events/h, SA was present in 65.7% of patients after acute MI. Mild SA was present in 32.6%, moderate in 20.4% and severe in 12.7%. The day-night variation in the onset of MI in all groups of SA patients was similar to that observed in non-SA patients. From 6 AM to 12 PM, the frequency of MI was higher in both SA and non-SA patients, as compared to the interval from 12 AM to 6 AM (all p<0.05).
CONCLUSION: There is a high prevalence of SA in patients presenting with acute MI. Peak time of MI onset in SA patients was between 6 AM and noon, similar to that in the general population. Whether diagnosis and treatment of SA after MI will significantly improve outcomes in these patients remains to be determined.
Authors:
Ondrej Ludka; Radka Stepanova; Martina Vyskocilova; Lujza Galkova; Monika Mikolaskova; Milos Belehrad; Jana Kostalova; Zuzana Mihalova; Adela Drozdova; Jiri Hlasensky; Michal Gacik; Lucie Pudilova; Tereza Mikusova; Blanka Fischerova; Fatima Sert-Kuniyoshi; Virend K Somers; Jindrich Spinar; Tomas Kara
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2014-06-27
Journal Detail:
Title:  International journal of cardiology     Volume:  176     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2014 Sep 
Date Detail:
Created Date:  2014-08-18     Completed Date:  -     Revised Date:  2014-12-02    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  13-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.
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Grant Support
ID/Acronym/Agency:
R01 HL065176/HL/NHLBI NIH HHS; R01 HL65176/HL/NHLBI NIH HHS

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