Document Detail


Sleep fragmentation and intermittent hypoxemia are associated with decreased insulin sensitivity in obese adolescent Latino males.
MedLine Citation:
PMID:  22669298     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Although sleep-related breathing disorder (SRBD) has been linked to insulin resistance in adults, this has not been as well established in children. We hypothesized that the severity of SRBD in adolescents was associated with metabolic impairment.
METHODS: Polysomnography was performed on obese, Latino males referred for snoring. The frequently sampled intravenous glucose tolerance test was used to assess glucose homeostasis. Total-body dual-energy X-ray absorptiometry was used to quantify adiposity.
RESULTS: A total of 22 males (mean age ± SD: 13.4 ± 2.1 y, BMI z-score 2.4 ± 0.3, obstructive apnea hypopnea index 4.1 ± 3.2) were studied. After correcting for age and adiposity in multiple-regression models, Log frequency of desaturation (defined as ≥3% drop in oxygen saturation from baseline) negatively correlated with insulin sensitivity. Sleep efficiency was positively correlated with glucose effectiveness (S(G), the capacity of glucose to mediate its own disposal). The Log total arousal index was positively correlated with Log homeostasis model assessment-estimated insulin resistance.
CONCLUSION: Sleep fragmentation and intermittent hypoxemia are associated with metabolic impairment in obese adolescent Latino males independent of age and adiposity. We speculate that SRBD potentiates the risk for development of metabolic syndrome and type 2 diabetes in the obese adolescent population.
Authors:
Daniel J Lesser; Rajeev Bhatia; Winston H Tran; Flavia Oliveira; Ricardo Ortega; Thomas G Keens; Steven D Mittelman; Michael C K Khoo; Sally L Davidson Ward
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-06-05
Journal Detail:
Title:  Pediatric research     Volume:  72     ISSN:  1530-0447     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-24     Completed Date:  2012-12-28     Revised Date:  2014-07-29    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  293-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Anoxia / physiopathology*
Child
Hispanic Americans*
Humans
Insulin Resistance*
Male
Obesity / physiopathology*
Polysomnography
Sleep Disorders / physiopathology*
Grant Support
ID/Acronym/Agency:
EB001978/EB/NIBIB NIH HHS; HL090451/HL/NHLBI NIH HHS; M01 RR00047/RR/NCRR NIH HHS; P41 EB001978/EB/NIBIB NIH HHS; R21 HL090451/HL/NHLBI NIH HHS; U54 CA 116848/CA/NCI NIH HHS; UL1 TR000130/TR/NCATS NIH HHS
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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