Document Detail

Sleep following alcohol intoxication in healthy, young adults: effects of sex and family history of alcoholism.
MedLine Citation:
PMID:  21323679     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: This study evaluated sex and family history of alcoholism as moderators of subjective ratings of sleepiness/sleep quality and polysomnography (PSG) following alcohol intoxication in healthy, young adults.
METHODS: Ninety-three healthy adults [mean age 24.4 ± 2.7 years, 59 women, 29 subjects with a positive family history of alcoholism (FH+)] were recruited. After screening PSG, participants consumed alcohol (sex/weight adjusted dosing) to intoxication [peak breath alcohol concentration (BrAC) of 0.11 ± 0.01 g% for men and women] or matching placebo between 20:30 and 22:00 hours. Sleep was monitored using PSG between 23:00 and 07:00 hours. Participants completed the Stanford Sleepiness Scale and Karolinska Sleepiness Scale at bedtime and on awakening and a validated post-sleep questionnaire.
RESULTS: Following alcohol, total sleep time, sleep efficiency, nighttime awakenings, and wake after sleep onset were more disrupted in women than men, with no differences by family history status. Alcohol reduced sleep onset latency, sleep efficiency, and rapid eye movement sleep while increasing wakefulness and slow wave sleep across the entire night compared with placebo. Alcohol also generally increased sleep consolidation in the first half of the night, but decreased it during the second half. Sleepiness ratings were higher following alcohol, particularly in women at bedtime. Morning sleep quality ratings were lower following alcohol than placebo.
CONCLUSIONS: Alcohol intoxication increases subjective sleepiness and disrupts sleep objectively more in healthy women than in men, with no differences evident by family history of alcoholism status. Evaluating moderators of alcohol effects on sleep may provide insight into the role of sleep in problem drinking.
J Todd Arnedt; Damaris J Rohsenow; Alissa B Almeida; Sarah K Hunt; Manjusha Gokhale; Daniel J Gottlieb; Jonathan Howland
Related Documents :
21911579 - Computerized macular pathology diagnosis in spectral domain optical coherence tomograph...
6549349 - Antagonism of the effect of delta sleep-inducing peptide by naloxone in the rat.
23212799 - Refractive lenticule extraction (relex flex) and wavefront-optimized femto-lasik: compa...
23628349 - Cataract extraction outcomes and the prevalence of zonular insufficiency in retinitis p...
24852069 - Anti-vegf therapy in myopic choroidal neovascularization: long-term results.
23347379 - Contrast sensitivity in the 'good eye' of adult patients with severe impairment in the ...
23399379 - High-risk retinoblastoma based on international classification of retinoblastoma: analy...
14601849 - Intraocular irrigating solutions. a clinical study of bss plus and dextrose bicarbonate...
10149289 - Intraocular lenses.
Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural     Date:  2011-02-15
Journal Detail:
Title:  Alcoholism, clinical and experimental research     Volume:  35     ISSN:  1530-0277     ISO Abbreviation:  Alcohol. Clin. Exp. Res.     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-27     Completed Date:  2012-03-07     Revised Date:  2014-09-09    
Medline Journal Info:
Nlm Unique ID:  7707242     Medline TA:  Alcohol Clin Exp Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  870-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 by the Research Society on Alcoholism.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Age Factors
Alcoholic Beverages* / adverse effects
Alcoholic Intoxication / complications,  genetics*
Alcoholism / complications,  genetics*
Double-Blind Method
Polysomnography / methods
Sex Characteristics*
Sleep Stages / drug effects,  physiology*
Young Adult
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Pharmacokinetics of amantadine in cats.
Next Document:  Variation in genes encoding the neuroactive steroid synthetic enzymes 5?-reductase type 1 and 3?-red...