Document Detail

Sleep and EEG disturbances in a rat neurological mutant (taiep) with immobility episodes: a model of narcolepsy-cataplexy.
MedLine Citation:
PMID:  1713828     Owner:  NLM     Status:  MEDLINE    
The electroencephalographic sleep patterns recorded during short periods of time (3 h) of a neurological mutant rat (taiep) were studied. This rat exhibits, among other signs, immobility episodes that are similar to those observed in narcolepsy-cataplexy. We describe findings of long term (6 months) electroencephalographic studies done in 9 mutant and 5 control rats. The mutant rats present electroencephalographic and behavioral disorders consisting of: (a) bursts of cortical waxing and waning waves occurring during the drowsy state; in some animals this activity represents up to 25% of the total drowsiness time; (b) shortened sleep time; (c) fragmented paradoxical sleep; (d) immobility episodes when the animals are subjected to an emotional excitement; and (e) electrographic activity of paradoxical sleep without atonia during the immobility episodes. These findings show that the taiep mutant shows several aspects of narcolepsy-cataplexy and it may represent an experimental model for the study of this pathology.
G J Prieto; R Urbá-Holmgren; B Holmgren
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Electroencephalography and clinical neurophysiology     Volume:  79     ISSN:  0013-4694     ISO Abbreviation:  Electroencephalogr Clin Neurophysiol     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1991-09-09     Completed Date:  1991-09-09     Revised Date:  2008-09-09    
Medline Journal Info:
Nlm Unique ID:  0375035     Medline TA:  Electroencephalogr Clin Neurophysiol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  141-7     Citation Subset:  IM    
Departamento de Ciencias Fisiológicas, Universidad Autónoma de Puebla, Mexico.
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MeSH Terms
Cataplexy / genetics,  physiopathology*
Disease Models, Animal*
Movement Disorders / genetics,  physiopathology*
Narcolepsy / genetics,  physiopathology*
Rats, Mutant Strains
Sleep / physiology
Sleep Stages
Sleep, REM / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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