Document Detail


Skin vasodilation and analgesic effect of a topical nitric oxide-releasing hydrogel.
MedLine Citation:
PMID:  23756965     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
New approaches based on topical treatments are needed for treating pain and impaired dermal blood flow. We used a topical Pluronic F127 hydrogel containing S-nitrosoglutathione (GSNO) as a prodrug to generate free NO, an effector molecule that exerts both dermal vasodilation and antinociceptive effects. GSNO-containing hydrogels underwent gelation above 12 °C and released free NO at rates that were directly dependent on the GSNO concentration in the range of 50-150 mM. The topical application of this material led to dose-response dermal vasodilation in healthy volunteers and to a reduction of up to 50 % of the hypernociception intensity in Wistar rats that were subjected to inflammatory pain. Mechanistic investigations indicated that the antinociceptive effect of the topical F127/GSNO hydrogels is produced by the local activation of the cGMP/PKG/KATP channel-signaling pathway, which was stimulated by the free NO that diffused through the skin. These results expand the scope of the biomedical applications of this material and may represent a new approach for the topical treatment of inflammatory pain.
Authors:
Rafael Vercelino; Thiago Mattar Cunha; Elisa Silva Ferreira; Fernando Q Cunha; Sérgio H Ferreira; Marcelo G de Oliveira
Related Documents :
22920095 - Newer approaches to the treatment of acne vulgaris.
21423605 - Are we looking in the wrong place? implications for behavioural-based pain assessment i...
24020545 - Psoriasis.
24379905 - The uvb cutaneous inflammatory pain model: a reproducibility study in healthy volunteers.
15221725 - Pharmacologic approaches to geriatric pain management.
18186845 - Complete resolution of recurrent calciphylaxis with long-term intravenous sodium thiosu...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-6-12
Journal Detail:
Title:  Journal of materials science. Materials in medicine     Volume:  -     ISSN:  1573-4838     ISO Abbreviation:  J Mater Sci Mater Med     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-6-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9013087     Medline TA:  J Mater Sci Mater Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Institute of Chemistry, University of Campinas (UNICAMP), CP 6154, Campinas, SP, 13087-970, Brazil.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Biological evaluation of alginate-based hydrogels, with antimicrobial features by Ce(III) incorporat...
Next Document:  Surgical treatment of supra- and infratentorial epidural hematoma.