| Skin susceptibility in uninvolved skin of hand eczema patients and healthy controls. | |
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MedLine Citation:
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PMID: 1911297 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Basic physiological characteristics were examined in the uninvolved skin of 39 patients with hand eczema and in 39 healthy controls. Susceptibility to sodium lauryl sulphate (SLS)-induced irritant dermatitis was evaluated by the application of a single 24-h SLS patch test to the upper arm. Transepidermal water loss (TEWL) was measured by an evaporimeter, skin thickness by ultrasound A-scan, blood flow by laser-Doppler flowmetry and skin colour by a chroma meter using the L*a*b* system of the Commission Internationale de l'Eclairage (CIE). No difference in basal TEWL values was found between patients and controls. A decreased skin thickness was found in those with hand eczema as compared to the controls. The hand eczema patients had significantly increased L* and decreased b*-values compared to controls, indicating a more 'fair' skin. Susceptibility to SLS was increased only in patients with acute eczema, indicating that the presence of an active eczema increases the reactivity to irritants of distant uninvolved skin. |
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Authors:
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T Agner |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The British journal of dermatology Volume: 125 ISSN: 0007-0963 ISO Abbreviation: Br. J. Dermatol. Publication Date: 1991 Aug |
Date Detail:
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Created Date: 1991-10-31 Completed Date: 1991-10-31 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0004041 Medline TA: Br J Dermatol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 140-6 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Rigshospitalet, Copenhagen, Denmark. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adult Body Water / metabolism Color Dermatitis, Contact / etiology Eczema / physiopathology* Female Hand Dermatoses / physiopathology* Humans Male Middle Aged Patch Tests Regional Blood Flow / physiology Skin / pathology, physiopathology* Sodium Dodecyl Sulfate / adverse effects |
| Chemical | |
Reg. No./Substance:
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151-21-3/Sodium Dodecyl Sulfate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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