Document Detail

Skin susceptibility in uninvolved skin of hand eczema patients and healthy controls.
MedLine Citation:
PMID:  1911297     Owner:  NLM     Status:  MEDLINE    
Basic physiological characteristics were examined in the uninvolved skin of 39 patients with hand eczema and in 39 healthy controls. Susceptibility to sodium lauryl sulphate (SLS)-induced irritant dermatitis was evaluated by the application of a single 24-h SLS patch test to the upper arm. Transepidermal water loss (TEWL) was measured by an evaporimeter, skin thickness by ultrasound A-scan, blood flow by laser-Doppler flowmetry and skin colour by a chroma meter using the L*a*b* system of the Commission Internationale de l'Eclairage (CIE). No difference in basal TEWL values was found between patients and controls. A decreased skin thickness was found in those with hand eczema as compared to the controls. The hand eczema patients had significantly increased L* and decreased b*-values compared to controls, indicating a more 'fair' skin. Susceptibility to SLS was increased only in patients with acute eczema, indicating that the presence of an active eczema increases the reactivity to irritants of distant uninvolved skin.
T Agner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The British journal of dermatology     Volume:  125     ISSN:  0007-0963     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1991-10-31     Completed Date:  1991-10-31     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  140-6     Citation Subset:  IM    
Department of Dermatology, Rigshospitalet, Copenhagen, Denmark.
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MeSH Terms
Acute Disease
Body Water / metabolism
Dermatitis, Contact / etiology
Eczema / physiopathology*
Hand Dermatoses / physiopathology*
Middle Aged
Patch Tests
Regional Blood Flow / physiology
Skin / pathology,  physiopathology*
Sodium Dodecyl Sulfate / adverse effects
Reg. No./Substance:
151-21-3/Sodium Dodecyl Sulfate

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