Document Detail

Skin and soft tissue infection caused by non-tuberculous mycobacteria.
MedLine Citation:
PMID:  17217137     Owner:  NLM     Status:  MEDLINE    
SETTING: A medical centre in Taipei, Taiwan. OBJECTIVE: To investigate the trend and characteristics of patients with non-tuberculous mycobacteria (NTM) related skin and soft tissue infection. DESIGN: A total of 63 patients with culture-proven diseases were identified from January 1997 to December 2004. The medical records of all patients were reviewed. RESULTS: Twenty-seven patients were infected with rapidly growing mycobacteria (RGM), 19 with Mycobacterium marinum, six with M. avium complex (MAC), five with M. kansasii and six with other species. Most patients presented with a protracted cutaneous lesion without systemic symptoms, and two thirds of the patients had a history of exposure. Seventy-three per cent of the lesions involved the extremities. Underlying illness with suppressed immunity was documented in 30.2% of the patients, and was most prevalent in patients with MAC (100%) and M. kansasii (60%). Of the patients, 62% underwent at least one surgical intervention, and 77.8% received treatment with different antimicrobial combinations. Most patients (86%) recovered completely. Granulomatous inflammation was found in 88.9% of biopsied tissue associated with M. marinum infection, 31.8% with RGM and 25.0% with MAC. CONCLUSION: A combination of surgery and antimicrobials cured most patients with microbiologically proven localised NTM skin and soft tissue infection.
C H Liao; C C Lai; L W Ding; S M Hou; H C Chiu; S C Chang; P R Hsueh
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease     Volume:  11     ISSN:  1027-3719     ISO Abbreviation:  Int. J. Tuberc. Lung Dis.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-01-12     Completed Date:  2007-03-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9706389     Medline TA:  Int J Tuberc Lung Dis     Country:  France    
Other Details:
Languages:  eng     Pagination:  96-102     Citation Subset:  IM    
Department of Internal Medicine, Far-Eastern Memorial Hospital, Taipei, Taiwan.
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MeSH Terms
Aged, 80 and over
Child, Preschool
Combined Modality Therapy
Middle Aged
Mycobacterium Infections, Atypical / epidemiology,  therapy*
Retrospective Studies
Skin Diseases, Infectious / epidemiology,  microbiology*,  therapy*
Soft Tissue Infections / epidemiology,  microbiology*,  therapy*
Taiwan / epidemiology
Treatment Outcome

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