Document Detail


Skin sensitivity to UVB irradiation in systemic lupus erythematosus is not related to the level of apoptosis induction in keratinocytes.
MedLine Citation:
PMID:  16352635     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Accumulation of apoptotic cells has been suggested to be involved in the pathogenesis of systemic lupus erythematosus (SLE). As sunlight exposure is one of the factors that can trigger disease activity, we hypothesized that UV light may induce increased numbers of apoptotic cells in SLE. METHODS: Fourteen SLE patients and 16 controls were irradiated with UVB to determine their minimal erythemal dose (MED). Subsequently, skin was irradiated with 1 MED and 2 MED, respectively, and after 24 h skin biopsies were analysed immunohistologically for the number of apoptotic cells and presence of pyknotic nuclear debris. RESULTS: MED was significantly decreased in SLE patients and the presence of decreased MED was associated with a history of butterfly rash. Decreased MED was not related to other skin-related ACR criteria or to autoantibody specificities. No differences were detected in the numbers of apoptotic keratinocytes between patients and controls or in the amount of pyknotic nuclear debris following 1 and 2 MED irradiation, respectively. Absolute UVB doses were correlated with the number of apoptotic keratinocytes; dose-responses did not differ significantly between patients and controls. CONCLUSIONS: Increased sensitivity of SLE patients to UVB, although associated with a history of malar rash, is not related to increased induction of apoptosis or increased levels of secondary necrosis in the skin. Thus, compared with controls, UVB-induced apoptosis is not increased in SLE patients under physiological conditions.
Authors:
E Reefman; H Kuiper; M F Jonkman; P C Limburg; C G M Kallenberg; M Bijl
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Publication Detail:
Type:  Journal Article     Date:  2005-12-13
Journal Detail:
Title:  Rheumatology (Oxford, England)     Volume:  45     ISSN:  1462-0324     ISO Abbreviation:  Rheumatology (Oxford)     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-04-21     Completed Date:  2006-06-29     Revised Date:  2007-09-06    
Medline Journal Info:
Nlm Unique ID:  100883501     Medline TA:  Rheumatology (Oxford)     Country:  England    
Other Details:
Languages:  eng     Pagination:  538-44     Citation Subset:  AIM; IM    
Affiliation:
Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, 9700 RB Groningen, The Netherlands. e.reefman@med.umcg.nl
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MeSH Terms
Descriptor/Qualifier:
Adult
Apoptosis / radiation effects*
Cell Nucleus / pathology
Dose-Response Relationship, Radiation
Epidermis / pathology
Erythema / etiology
Female
Humans
Keratinocytes / pathology,  radiation effects*
Lupus Erythematosus, Systemic / pathology*
Male
Middle Aged
Radiation Dosage
Radiation Injuries / etiology,  pathology
Skin / pathology,  radiation effects*
Ultraviolet Rays*
Comments/Corrections
Comment In:
Rheumatology (Oxford). 2006 May;45(5):500-1   [PMID:  16467364 ]

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