Document Detail

Skin replica analysis of photodamaged skin after therapy with tretinoin emollient cream.
MedLine Citation:
PMID:  1918458     Owner:  NLM     Status:  MEDLINE    
Computerized image analysis of silicone replicas, a reproducible, objective technique for measuring skin topography, was used in addition to clinical measures in two multicenter, double-blind, randomized, controlled studies of tretinoin emollient cream, a new formulation for treating photodamaged skin. Previously, the skin replica technique had been successfully used in a pilot study of tretinoin 0.05% cream by one investigator. In the present studies, subjects treated for 24 weeks with tretinoin emollient 0.05% cream consistently showed more improvement in skin topography than did vehicle-treated patients. A 0.01% concentration of tretinoin emollient cream also improved skin topography to a greater extent than the vehicle, while the lowest concentration tested (0.001%) showed little difference from vehicle. These results, reflecting a smoothening of the skin surface in tretinoin emollient cream-treated subjects, were consistent with clinical data showing greater improvement in fine wrinkling and roughness after tretinoin emollient cream therapy than after vehicle therapy. Findings from these multicenter studies confirm the value of the skin replica technique and help establish the efficacy of tretinoin emollient 0.05% cream for photodamaged skin.
G L Grove; M J Grove; J J Leyden; L Lufrano; B Schwab; B H Perry; E G Thorne
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American Academy of Dermatology     Volume:  25     ISSN:  0190-9622     ISO Abbreviation:  J. Am. Acad. Dermatol.     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1991-11-12     Completed Date:  1991-11-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7907132     Medline TA:  J Am Acad Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  231-7     Citation Subset:  IM    
Skin Study Center, Broomall, PA 19008.
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MeSH Terms
Dose-Response Relationship, Drug
Double-Blind Method
Image Interpretation, Computer-Assisted / methods
Middle Aged
Replica Techniques*
Skin Aging / drug effects*
Tretinoin / therapeutic use*
Reg. No./Substance:
0/Emollients; 302-79-4/Tretinoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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