Document Detail


Skin rejuvenation using intense pulsed light: a randomized controlled split-face trial with blinded response evaluation.
MedLine Citation:
PMID:  16924047     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate efficacy and adverse effects of intense pulsed light rejuvenation in a homogeneous group of patients. DESIGN: Randomized controlled split-face trial. SETTING: University dermatology department. PATIENTS: Thirty-two female volunteers with Fitzpatrick skin type I through III and class I or II rhytids. INTERVENTIONS: Subjects were randomized to 3 intense pulsed light treatments at 1-month intervals or to no treatment of right or left sides of the face. MAIN OUTCOME MEASURES: Primary end points were skin texture and rhytids. Secondary end points were telangiectasia, irregular pigmentation, and adverse effects. Efficacy was evaluated by patient self-assessments and by blinded clinical and photographic evaluations up to 9 months after final treatment. Adverse effects were assessed clinically and by noninvasive skin reflectance measurements. RESULTS: Skin texture was significantly improved at all clinical assessments except at the 6-month examination (P<.006). The improvements peaked at 1 month after treatment, at which time 23 (82%) of 28 patients had better appearances of treated vs untreated sides. Most patients obtained mild or moderate improvements, and 16 patients (58%) self-reported mild or moderate efficacy on skin texture. Rhytids were not significantly different on treated vs untreated sides, and 19 patients (68%) reported uncertain or no efficacy on rhytids. Significant improvements of telangiectasia (P<.001) and irregular pigmentation (P<.03) were found at all assessments. Three patients withdrew from the study because of pain related to treatment. CONCLUSIONS: Three intense pulsed light treatments improved skin texture, telangiectasia, and irregular pigmentation but had no efficacy on rhytids. Adverse events were minimal, but included scar in 1 patient.
Authors:
Lene Hedelund; Eva Due; Peter Bjerring; Hans Christian Wulf; Merete Haedersdal
Related Documents :
6379077 - Dupuytren's contracture: a comparative study of fasciectomy and dermofasciectomy in one...
11453807 - Long-pulsed nd:yag laser-assisted hair removal in pigmented skin: a clinical and histol...
19807827 - Photoepilation with variable pulsed light in non-facial body areas: evaluation of effic...
12410677 - Nonablative remodeling: a 14-month clinical ultrasound imaging and profilometric evalua...
9558287 - "salvage" transjugular intrahepatic portosystemic shunts: gastric fundal compared with ...
18705307 - The clinical characteristics, endoscopic treatment, and prognosis for patients presenti...
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Archives of dermatology     Volume:  142     ISSN:  0003-987X     ISO Abbreviation:  Arch Dermatol     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-08-22     Completed Date:  2006-09-11     Revised Date:  2008-03-17    
Medline Journal Info:
Nlm Unique ID:  0372433     Medline TA:  Arch Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  985-90     Citation Subset:  AIM; IM    
Affiliation:
Department of Dermatology, University of Copenhagen and Bispebjerg Hospital, Bispebjerg Bakke 23, DK-2400 Copenhagen, Denmark. LH20@bbh.hosp.dk
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Double-Blind Method
Facial Dermatoses / pathology,  therapy*
Female
Humans
Middle Aged
Phototherapy*
Rejuvenation
Severity of Illness Index
Skin Aging*
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Facial resurfacing for nonmelanoma skin cancer prophylaxis.
Next Document:  Bilateral facial capillary malformation associated with eye and brain abnormalities.