| Skin rejuvenation using intense pulsed light: a randomized controlled split-face trial with blinded response evaluation. | |
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MedLine Citation:
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PMID: 16924047 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate efficacy and adverse effects of intense pulsed light rejuvenation in a homogeneous group of patients. DESIGN: Randomized controlled split-face trial. SETTING: University dermatology department. PATIENTS: Thirty-two female volunteers with Fitzpatrick skin type I through III and class I or II rhytids. INTERVENTIONS: Subjects were randomized to 3 intense pulsed light treatments at 1-month intervals or to no treatment of right or left sides of the face. MAIN OUTCOME MEASURES: Primary end points were skin texture and rhytids. Secondary end points were telangiectasia, irregular pigmentation, and adverse effects. Efficacy was evaluated by patient self-assessments and by blinded clinical and photographic evaluations up to 9 months after final treatment. Adverse effects were assessed clinically and by noninvasive skin reflectance measurements. RESULTS: Skin texture was significantly improved at all clinical assessments except at the 6-month examination (P<.006). The improvements peaked at 1 month after treatment, at which time 23 (82%) of 28 patients had better appearances of treated vs untreated sides. Most patients obtained mild or moderate improvements, and 16 patients (58%) self-reported mild or moderate efficacy on skin texture. Rhytids were not significantly different on treated vs untreated sides, and 19 patients (68%) reported uncertain or no efficacy on rhytids. Significant improvements of telangiectasia (P<.001) and irregular pigmentation (P<.03) were found at all assessments. Three patients withdrew from the study because of pain related to treatment. CONCLUSIONS: Three intense pulsed light treatments improved skin texture, telangiectasia, and irregular pigmentation but had no efficacy on rhytids. Adverse events were minimal, but included scar in 1 patient. |
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Authors:
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Lene Hedelund; Eva Due; Peter Bjerring; Hans Christian Wulf; Merete Haedersdal |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Archives of dermatology Volume: 142 ISSN: 0003-987X ISO Abbreviation: Arch Dermatol Publication Date: 2006 Aug |
Date Detail:
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Created Date: 2006-08-22 Completed Date: 2006-09-11 Revised Date: 2008-03-17 |
Medline Journal Info:
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Nlm Unique ID: 0372433 Medline TA: Arch Dermatol Country: United States |
Other Details:
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Languages: eng Pagination: 985-90 Citation Subset: AIM; IM |
Affiliation:
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Department of Dermatology, University of Copenhagen and Bispebjerg Hospital, Bispebjerg Bakke 23, DK-2400 Copenhagen, Denmark. LH20@bbh.hosp.dk |
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| MeSH Terms | |
Descriptor/Qualifier:
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Double-Blind Method Facial Dermatoses / pathology, therapy* Female Humans Middle Aged Phototherapy* Rejuvenation Severity of Illness Index Skin Aging* Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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