Document Detail

Skin preservation at a supraphysiologic temperature and induction of epithelial cysts by subcutaneous grafting: attempts to simplify evaluation of storage media and of graft viability.
MedLine Citation:
PMID:  15263829     Owner:  NLM     Status:  MEDLINE    
This pilot study used a new experimental rat model designed to explore whether in-depth investigation of the following two questions would be reasonable: (1) Can skin storage media be faster evaluated by storing skin at a supraphysiologic temperature, and (2) can evaluation of skin graft viability be facilitated by subcutaneous grafting leading to production of epithelial cysts from the viable portions of the grafts? The experiment involved skin storage at 47.3 degrees C in saline and in 10% Dextran 40 solution for periods ranging from 0 to 18 min, followed by subcutaneous grafting. The surface area of the resultant epithelial cysts and the cyst-to-graft ratio inversely correlated with storage time, which is in accordance with a well-established analogous relationship involving the rate of graft 'take'. The skin tended to remain viable longer in Dextran 40 solution, which is consistent with previous studies of low temperature storage demonstrating superiority of high-molecular-weight solutions. The results warrant further investigation of the above issues.
V Macionis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes     Volume:  36     ISSN:  0014-312X     ISO Abbreviation:  Eur Surg Res     Publication Date:    2004 Jul-Aug
Date Detail:
Created Date:  2004-07-20     Completed Date:  2005-01-14     Revised Date:  2006-11-30    
Medline Journal Info:
Nlm Unique ID:  0174752     Medline TA:  Eur Surg Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  234-40     Citation Subset:  IM    
Copyright Information:
Copyright 2004 S. Karger AG, Basel
Clinic of Orthopaedics, Traumatology and Plastic Surgery at Vilnius University Faculty of Medicine, Department of Plastic and Reconstructive Surgery at Vilnius University Hospital, Vilnius, Lithuania.
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MeSH Terms
Cysts / pathology*
Epithelium / pathology
Graft Survival / physiology*
Models, Animal
Organ Preservation
Pilot Projects
Postoperative Complications / pathology
Rats, Wistar
Skin Transplantation / methods*
Subcutaneous Tissue / pathology*,  surgery

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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