Document Detail

Skin polyamine levels in psoriasis: the effect of dithranol therapy.
MedLine Citation:
PMID:  100325     Owner:  NLM     Status:  MEDLINE    
Concentrations of putrescine, spermidine and spermine were determined in biopsies of skin of eight control subjects and of uninvolved skin and skin lesions of eight psoriatic patients before and after topical therapy with dithranol. Mean spermidine and spermine concentrations in uninvolved skin of psoriatic patients were normal, but putrescine concentration was elevated. In psoriatic skin lesions all three amines were significantly elevated. Chemotherapy effectively reduced polyamine concentrations in involved skin touards normal. This decrease in polyamine levels correlated with reduction of the proliferative activity of the epidermis and with clinical improvement of the patients.
P Bohlen; J Grove; M F Beya; J Koch-Weser; M H Henry; E Grosshans
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of clinical investigation     Volume:  8     ISSN:  0014-2972     ISO Abbreviation:  Eur. J. Clin. Invest.     Publication Date:  1978 Aug 
Date Detail:
Created Date:  1978-12-27     Completed Date:  1978-12-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0245331     Medline TA:  Eur J Clin Invest     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  215-8     Citation Subset:  IM    
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MeSH Terms
Anthracenes / pharmacology*
Anthralin / pharmacology*,  therapeutic use
Middle Aged
Mitosis / drug effects
Polyamines / metabolism*
Psoriasis / drug therapy,  metabolism*,  pathology
Skin / drug effects,  metabolism*,  pathology
Reg. No./Substance:
0/Anthracenes; 0/Polyamines; 480-22-8/Anthralin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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