Document Detail

Skin pigmentation due to minocycline treatment of facial dermatoses.
MedLine Citation:
PMID:  7654575     Owner:  NLM     Status:  MEDLINE    
Fifty-four patients taking minocycline for acne or rosacea were assessed for adverse effects. Their mean duration of treatment was 17 months, and their average cumulative dose was 47 g. No symptoms attributable to the therapy were reported. Biochemistry and haematology profiles were normal. There was no evidence of an adverse effect on thyroid function. Skin pigmentation was detected in eight patients (14.8%). Five patients had diffuse facial pigmentation, and three patients had localized pigmentation at the site of a scar or injury. Diffuse pigmentation occurred only in patients who had been on treatment for 3 years or more; 50% of such patients were affected. Age and solar damage may also have been factors in this type of pigmentation. Localized pigmentation occurred at sites of previous tissue damage, and was not directly related to the duration of therapy. Patients who receive long-term minocycline therapy should be regularly monitored for the development of pigmentation.
C M Dwyer; A M Cuddihy; R E Kerr; R S Chapman; B F Allam
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The British journal of dermatology     Volume:  129     ISSN:  0007-0963     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  1993 Aug 
Date Detail:
Created Date:  1995-10-02     Completed Date:  1995-10-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  158-62     Citation Subset:  IM    
Department of Dermatology, Stobhill General Hospital, Glasgow, U.K.
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MeSH Terms
Acne Vulgaris / drug therapy
Age Factors
Cicatrix / pathology
Facial Dermatoses / drug therapy*
Middle Aged
Minocycline / administration & dosage,  adverse effects*
Pigmentation Disorders / chemically induced*,  pathology
Rosacea / drug therapy
Skin Aging
Skin Pigmentation / drug effects
Thyroid Gland / drug effects
Thyrotropin / blood
Thyroxine / analysis
Time Factors
Reg. No./Substance:
10118-90-8/Minocycline; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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