| Skin pigmentation due to minocycline treatment of facial dermatoses. | |
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MedLine Citation:
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PMID: 7654575 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fifty-four patients taking minocycline for acne or rosacea were assessed for adverse effects. Their mean duration of treatment was 17 months, and their average cumulative dose was 47 g. No symptoms attributable to the therapy were reported. Biochemistry and haematology profiles were normal. There was no evidence of an adverse effect on thyroid function. Skin pigmentation was detected in eight patients (14.8%). Five patients had diffuse facial pigmentation, and three patients had localized pigmentation at the site of a scar or injury. Diffuse pigmentation occurred only in patients who had been on treatment for 3 years or more; 50% of such patients were affected. Age and solar damage may also have been factors in this type of pigmentation. Localized pigmentation occurred at sites of previous tissue damage, and was not directly related to the duration of therapy. Patients who receive long-term minocycline therapy should be regularly monitored for the development of pigmentation. |
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Authors:
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C M Dwyer; A M Cuddihy; R E Kerr; R S Chapman; B F Allam |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The British journal of dermatology Volume: 129 ISSN: 0007-0963 ISO Abbreviation: Br. J. Dermatol. Publication Date: 1993 Aug |
Date Detail:
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Created Date: 1995-10-02 Completed Date: 1995-10-02 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0004041 Medline TA: Br J Dermatol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 158-62 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Stobhill General Hospital, Glasgow, U.K. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acne Vulgaris
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drug therapy Adolescent Adult Age Factors Aged Cicatrix / pathology Facial Dermatoses / drug therapy* Female Humans Male Middle Aged Minocycline / administration & dosage, adverse effects* Pigmentation Disorders / chemically induced*, pathology Rosacea / drug therapy Skin Aging Skin Pigmentation / drug effects Thyroid Gland / drug effects Thyrotropin / blood Thyroxine / analysis Time Factors |
| Chemical | |
Reg. No./Substance:
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10118-90-8/Minocycline; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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