Document Detail


Skin permeation of cacalol, cacalone and 6-epi-cacalone sesquiterpenes from a nanoemulsion.
MedLine Citation:
PMID:  22908555     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
The objective of the present study was to investigate the transdermal permeation of cacalol (1) and a mixture of cacalone (2) and 6-epi-cacalone (3) in comparison with diclofenac acid (4) delivered from the same characterized nanoemulsion using Franz diffusion cells (formulae I, II and III). Results show that de Kp, J, Q24, PI and P2 were higher for the acid diclofenac nanoemulsion than for the natural products nanoemulsions. As for the differences between the formulations I and II, with the natural products, Q24, the quantity extracted from skin and P2 were higher in the mixture of 2 and 3 nanoemulsion compared with the corresponding nanoemulsion of 1. In conclusion, the low permeability of the natural products nanoemulsions in comparison with that of diclofenac acid has the potential for development for drugs with local and systemic applications, respectively.
Authors:
María Luisa Garduño-Ramírez; Beatriz Clares; Valeri Domínguez-Villegas; Concepción Peraire; María Adolfina Ruiz; María Luisa García; Ana C Calpena
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Natural product communications     Volume:  7     ISSN:  1934-578X     ISO Abbreviation:  Nat Prod Commun     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-08-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101477873     Medline TA:  Nat Prod Commun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  821-3     Citation Subset:  IM    
Affiliation:
Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos 62209, México. Igarduno@uaem.mx
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