Document Detail


Skin peptides: biological activity and therapeutic opportunities.
MedLine Citation:
PMID:  17914716     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The skin provides an effective barrier to the loss of body fluids and environmental assault. In addition to the physical barrier provided by the stratum corneum, the skin also contains a chemical barrier consisting of antimicrobial peptides (AMPs), which control microbial growth on the surface. These AMPs also have multiple roles as mediators of inflammation with effects on epithelial and inflammatory cells, influencing cell proliferation, wound healing, cytokine/chemokine production and chemotaxis. This review describes the range of peptides found in the skin, both constitutive and those induced in response to injury. The role these peptides play in normal skin function and in various skin conditions is described. A better understanding of their role in normal and skin disease may offer new strategies in skin disease, dermatology and as cosmeceuticals.
Authors:
Sarika Namjoshi; Rima Caccetta; Heather A E Benson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pharmaceutical sciences     Volume:  97     ISSN:  1520-6017     ISO Abbreviation:  J Pharm Sci     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-04     Completed Date:  2008-10-09     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  2985195R     Medline TA:  J Pharm Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2524-42     Citation Subset:  IM    
Affiliation:
School of Pharmacy, Curtin University of Technology, Perth, Western Australia, Australia.
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MeSH Terms
Descriptor/Qualifier:
Animals
Humans
Peptides* / immunology,  metabolism,  physiology,  therapeutic use
Skin / drug effects,  immunology,  metabolism*,  microbiology
Skin Diseases* / drug therapy,  immunology,  metabolism
Skin Physiological Phenomena* / drug effects,  immunology
Wound Healing* / drug effects,  physiology
Chemical
Reg. No./Substance:
0/Peptides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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