| Skin peptides: biological activity and therapeutic opportunities. | |
| | |
MedLine Citation:
|
PMID: 17914716 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The skin provides an effective barrier to the loss of body fluids and environmental assault. In addition to the physical barrier provided by the stratum corneum, the skin also contains a chemical barrier consisting of antimicrobial peptides (AMPs), which control microbial growth on the surface. These AMPs also have multiple roles as mediators of inflammation with effects on epithelial and inflammatory cells, influencing cell proliferation, wound healing, cytokine/chemokine production and chemotaxis. This review describes the range of peptides found in the skin, both constitutive and those induced in response to injury. The role these peptides play in normal skin function and in various skin conditions is described. A better understanding of their role in normal and skin disease may offer new strategies in skin disease, dermatology and as cosmeceuticals. |
| | |
Authors:
|
Sarika Namjoshi; Rima Caccetta; Heather A E Benson |
Related Documents
:
|
17712996 - Network of myeloid and plasmacytoid dendritic cells in atopic dermatitis. 7694646 - The role of cytokines in the psoriatic inflammation. 18620136 - Antimicrobial peptides, skin infections, and atopic dermatitis. 15358566 - Allergic contact dermatitis. 22267936 - Immune parameters, symptoms of upper respiratory tract infections, and training-load in... 9056426 - Altered gene expression associated with apoptosis in a pre-b-leukemic cell line followi... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of pharmaceutical sciences Volume: 97 ISSN: 1520-6017 ISO Abbreviation: J Pharm Sci Publication Date: 2008 Jul |
Date Detail:
|
Created Date: 2008-06-04 Completed Date: 2008-10-09 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 2985195R Medline TA: J Pharm Sci Country: United States |
Other Details:
|
Languages: eng Pagination: 2524-42 Citation Subset: IM |
Affiliation:
|
School of Pharmacy, Curtin University of Technology, Perth, Western Australia, Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Humans Peptides* / immunology, metabolism, physiology, therapeutic use Skin / drug effects, immunology, metabolism*, microbiology Skin Diseases* / drug therapy, immunology, metabolism Skin Physiological Phenomena* / drug effects, immunology Wound Healing* / drug effects, physiology |
| Chemical | |
Reg. No./Substance:
|
0/Peptides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Controlling the type 1 error rate in non-inferiority trials.
Next Document: N-in-1 dosing pharmacokinetics in drug discovery: experience, theoretical and practical consideratio...