Document Detail

Skin necrosis due to fluindione treatment: a rare but serious complication.
MedLine Citation:
PMID:  24526169     Owner:  NLM     Status:  In-Data-Review    
In the setting of protein C deficiency, skin necrosis, which occurs most often at the initial phase of oral anticoagulants therapy, is a rare side effect. Six cases have previously been reported in the literature. In this case report, we present a protein C deficient 42-year-old woman who was being treated for venous thrombosis. Five days after the initiation of oral anticoagulant treatment, she developed extensive skin necrosis on her left calf, followed by a painful leg ulcer. The pathogenesis underlying skin necrosis caused by anticoagulation therapy is still not clear. Despite only a few cases being reported in the literature, it is important to recognise this complication since adequate therapeutic approaches leading to a stable anticoagulation state may prevent it.
K Beqqal; Mh Horellou; A Philippe; M Alhene Gelas; C Flaujac; I Gorin; S Jacobelli; N Dupin; B Hassam; Mf Avril
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of wound care     Volume:  23 Suppl 1     ISSN:  0969-0700     ISO Abbreviation:  J Wound Care     Publication Date:  2014 Feb 
Date Detail:
Created Date:  2014-02-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9417080     Medline TA:  J Wound Care     Country:  England    
Other Details:
Languages:  eng     Pagination:  S16-9     Citation Subset:  N    
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