Document Detail

Skin necrosis after warfarin therapy.
MedLine Citation:
PMID:  368994     Owner:  NLM     Status:  MEDLINE    
A rare but potentially lethal complication of coumarin and its congeners is skin necrosis. A case of skin necrosis due to warfarin is reported and the literature is reviewed. It is suggested that if necrosis develops, the coumarin therapy should be terminated, and the patient should immediately be heparinized. Heparin, which never causes necrosis, can be used freely if further anticoagulation therapy is required, and may well prevent necrosis due to the thrombotic process.
M S Elliot; E J Immelman; P Jeffery; S R Benatar; M R Funston; J A Smith; P Jacobs; B J Shepstone; A D Ferguson; J H Louw
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde     Volume:  54     ISSN:  0256-9574     ISO Abbreviation:  S. Afr. Med. J.     Publication Date:  1978 Oct 
Date Detail:
Created Date:  1979-04-28     Completed Date:  1979-04-28     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  0404520     Medline TA:  S Afr Med J     Country:  SOUTH AFRICA    
Other Details:
Languages:  eng     Pagination:  609-10     Citation Subset:  IM    
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MeSH Terms
Pregnancy Complications, Hematologic
Skin Diseases, Vesiculobullous / chemically induced*
Warfarin / adverse effects*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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