Document Detail

Skin and muscle involvement as presenting symptoms in four children with familial Mediterranean fever.
MedLine Citation:
PMID:  19240979     Owner:  NLM     Status:  MEDLINE    
Familial Mediterranean fever (FMF) is an autosomal recessive disorder characterized by recurrent attacks of fever and polyserositis. It is the most frequent periodic fever syndrome. In FMF, sterile peritonitis, pleuritis and arthritis are frequently seen in addition to recurrent febrile attacks. Skin and muscle involvement is less common. Here, we report four patients presented with skin lesions or myalgia. Most striking findings in those patients are the absence of other major criteria for FMF and dominancy of skin lesions or myalgia. All four patients had MEFV gene mutations on both alleles. In patients with erysipelas-like lesions or erythema nodosum along with arthritis/arthralgia or recurrent myalgia, FMF should be kept in mind.
Salih Kavukcu; Mehmet Türkmen; Alper Soylu; Belde Kasap; Burçak Tatli Güneş
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2009-02-25
Journal Detail:
Title:  Clinical rheumatology     Volume:  28     ISSN:  1434-9949     ISO Abbreviation:  Clin. Rheumatol.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-05-27     Completed Date:  2009-08-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211469     Medline TA:  Clin Rheumatol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  857-60     Citation Subset:  IM    
Departments of Pediatrics, School of Medicine, Dokuz Eylül University, Mithatpaşa Cad. 665/4, Küçükyali, 35280, Izmir, Turkey.
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MeSH Terms
Colchicine / therapeutic use
Erythema Nodosum / diagnosis,  etiology,  physiopathology
Familial Mediterranean Fever / complications,  diagnosis*,  drug therapy
Muscle, Skeletal / pathology*
Muscular Diseases / diagnosis*,  drug therapy,  etiology
Remission Induction
Skin / pathology*
Skin Diseases / diagnosis*,  drug therapy,  etiology
Treatment Outcome
Reg. No./Substance:

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