Document Detail

Skin microvascular dilatation response to acetylcholine and sodium nitroprusside in peripheral arterial disease.
MedLine Citation:
PMID:  12464139     Owner:  NLM     Status:  MEDLINE    
The relative magnitude of endothelial versus non-endothelial vasodilatation in the skin of limbs of patients with peripheral arterial occlusive disease (PAOD) is not known. We therefore investigated the effects of iontophoretically administered sodium nitroprusside (SNP) and acetylcholine (Ach) on the skin microvascular blood flow measured by laser-Doppler fluxmetry. METHODS: Blood flow changes in the skin was measured on the dorsal side of the foot in three different groups: (i). 11 patients (mean age 73 years) with PAOD, with a mean ankle-brachial index of 0.46, (ii). eight age-matched elderly healthy volunteers (mean age 73 years) and (iii). young healthy group (n=15; mean age 34 years). For drug administration with iontophoretic technique we used a Periont Micropharmacology System. RESULTS: In patients with PAOD, Ach produced a vasodilatation, which was directly correlated to the strength of iontophoretic stimulation. The difference between the patients and the elderly healthy group was significant after the highest stimulation (160 s, P<0.05). The same pattern was found during stimulation with SNP. In comparison with the young healthy group there was a statistically significant difference (P<0.001) with a slower and less pronounced response in patients with PAOD. CONCLUSION: In patients with PAOD it is possible to achieve local vasodilatation from a baseline level by delivering Ach or SNP through the skin. The two vasodilators, acting by different mechanisms, produced the same vasodilatation response, suggesting that the impaired vasodilatation capacity in patients with peripheral arterial disease may not emanate primarily from local endothelial dysfunction in the skin microcirculation.
Christina Jägrén; Bertil Gazelius; Christina Ihrman-Sandal; Lars-Eric Lindblad; Jan Ostergren
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Clinical physiology and functional imaging     Volume:  22     ISSN:  1475-0961     ISO Abbreviation:  Clin Physiol Funct Imaging     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-12-04     Completed Date:  2003-05-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101137604     Medline TA:  Clin Physiol Funct Imaging     Country:  England    
Other Details:
Languages:  eng     Pagination:  370-4     Citation Subset:  IM    
Department of Cardiology, Karolinska Institute at Söder Hospital, Stockholm, Sweden.
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MeSH Terms
Acetylcholine / administration & dosage*
Age Factors
Aged, 80 and over
Laser-Doppler Flowmetry
Microcirculation / drug effects
Nitroprusside / administration & dosage*
Peripheral Vascular Diseases / drug therapy*
Regional Blood Flow / drug effects
Skin / blood supply*
Vasodilation / drug effects
Vasodilator Agents / administration & dosage*
Reg. No./Substance:
0/Vasodilator Agents; 15078-28-1/Nitroprusside; 51-84-3/Acetylcholine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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