Document Detail

Skin manifestations of mustard gas. A clinical study of 535 patients exposed to mustard gas.
MedLine Citation:
PMID:  1599263     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: During the Iraq-Iran war (1980-1988), 535 patients who were exposed to mustard gas (one of the chemical warfare agents used by Iraq) were referred to our dermatology department. In this article, we have tried to review the skin manifestations of these patients. OBSERVATIONS: The skin lesions were of early or late onset. The early onset lesions consisted of erythema (76%), bulla (55%), and purpura (1.1%). These lesions were mostly found on the face and skin folds. The late-onset manifestations were pigmentation (20.4%) and desquamation (11.2%). Other complications were ophthalmic (85%), pulmonary (15%), and gastrointestinal (10%). Lymphopenia (7%) was the most serious laboratory disorder reported. Biopsy specimens of the lesions showed subepidermal bullae with mild dermal and epidermal necrosis. CONCLUSIONS: All patients were treated as for burns using sulfadiazine and furacine. All patients were cured in a period of 15 to 45 days. During a 6-month follow-up, no mortality was observed.
A Z Momeni; S Enshaeih; M Meghdadi; M Amindjavaheri
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of dermatology     Volume:  128     ISSN:  0003-987X     ISO Abbreviation:  Arch Dermatol     Publication Date:  1992 Jun 
Date Detail:
Created Date:  1992-07-06     Completed Date:  1992-07-06     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  0372433     Medline TA:  Arch Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  775-80     Citation Subset:  AIM; IM    
Department of Dermatology, Isfahan University of Medical Sciences.
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MeSH Terms
Anemia / chemically induced
Blister / chemically induced
Combined Modality Therapy
Conjunctivitis / chemically induced,  therapy
Erythema / chemically induced,  therapy
Mustard Gas / adverse effects*
Pigmentation Disorders / chemically induced,  therapy
Skin Diseases / chemically induced*,  pathology,  therapy
Skin Diseases, Vesiculobullous / chemically induced,  therapy
Thrombocytopenia / chemically induced
Time Factors
Urticaria / chemically induced,  therapy
Reg. No./Substance:
505-60-2/Mustard Gas
Comment In:
Arch Dermatol. 1993 Feb;129(2):245   [PMID:  8434986 ]

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