| Skin and joint infection by Mycobacterium chelonae: rescue treatment with interferon gamma. | |
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MedLine Citation:
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PMID: 17613267 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Atypical mycobacteria are environmental organisms that cause opportunistic infections in humans. CASE REPORT: A 50-year-old electronics engineer sought advice about starting TNFalpha antagonist therapy for ankylosing spondylitis. Disease duration was 23 years and current treatment was methylprednisolone 4 mg/d. Atypical skin lesions and knee arthritis were noted. Fluid aspirated from the knee showed inflammatory properties and a few acid-fast bacteria, which a line probe assay identified as Mycobacterium chelonae. The same organism was found in a skin biopsy from a thigh lesion. Antimicrobial treatment was started immediately. Inadequate results 6 months later prompted synovectomy of the knee followed by interferon gamma, 50 microg/m(2) body surface area subcutaneously 3 times a week. After 16 months, there were no new skin or joint lesions, and the antimicrobials and interferon gamma were therefore discontinued. CONCLUSION: This highly unusual case suggests that interferon gamma may be effective in patients with M. chelonae infection that fails to respond adequately to antimicrobials. |
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Authors:
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Sandrine Jousse-Joulin; Michel Garre; Xavier Guennoc; Claire Destombe; Isabelle Samjee; Valérie Devauchelle-Pensec; Alain Saraux |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2007-05-29 |
Journal Detail:
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Title: Joint, bone, spine : revue du rhumatisme Volume: 74 ISSN: 1778-7254 ISO Abbreviation: Joint Bone Spine Publication Date: 2007 Jul |
Date Detail:
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Created Date: 2007-07-19 Completed Date: 2007-09-11 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 100938016 Medline TA: Joint Bone Spine Country: France |
Other Details:
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Languages: eng Pagination: 385-8 Citation Subset: IM |
Affiliation:
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Rheumatology Department, Brest Teaching Hospital, Brest, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Arthritis, Reactive
/
diagnosis,
drug therapy*,
surgery Follow-Up Studies Humans Interferon-gamma / therapeutic use* Knee Joint Male Methylprednisolone / adverse effects, therapeutic use Middle Aged Mycobacterium Infections, Atypical / diagnosis*, drug therapy* Mycobacterium chelonae / isolation & purification* Orthopedic Procedures Risk Assessment Skin Diseases, Bacterial / diagnosis, drug therapy* Spondylitis, Ankylosing / diagnosis, drug therapy Treatment Failure |
| Chemical | |
Reg. No./Substance:
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82115-62-6/Interferon-gamma; 83-43-2/Methylprednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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